Citation
Chua K. H., . and Ong K. C., . and Kuppusamy U. R., . and Nallappan D., . and Palanisamy U. D., . Safety assessment and oxidative stress evaluation of myricetin derivative-rich fraction from Syzygium malaccense in C57BL/6J mice. pp. 803-815. ISSN 22317546
Abstract
Myricetin derivatives from Syzygium malaccense leaf extract are known to have numerous therapeutic efficacies but there is no documented evidence corroborating its safety. Therefore the present work aimed to evaluate the safety profile of myricetin derivative-rich fraction (MD) from S. malaccense leaf extract through single and repetitive oral administration in C57BL/6J mice. In the acute toxicity study mice were orally administered with MD at single doses of 25 150 500 and 1 500 mg/kg. Subsequently a modified sub-chronic toxicity assessment was performed by administering 150 mg/kg MD orally for 16 weeks. In both acute and sub-chronic toxicity studies there were no lethal effects and behavioural signs of toxicity observed. The body weight food and water intakes of mice were normal throughout the respective experimental periods. As compared to the respective control groups MD caused a significant improvement in serum uric acid and aspartate aminotransferase levels. The histopathological analysis of MD-administered mice did not show any inflammation or cell death. The MD-treated mice showed significantly reduced protein carbonyl and lipid hydroperoxide levels in urine liver and kidney tissues. Taken together the no-observed-adverse-effect level of MD was up to 1 500 mg/kg and considered safe for oral consumption over relatively long durations with oxidative stress attenuating properties.
Download File
Full text available from:
Official URL: http://www.ifrj.upm.edu.my/28%20(04)%202021/DONE%2...
|
Abstract
Myricetin derivatives from Syzygium malaccense leaf extract are known to have numerous therapeutic efficacies but there is no documented evidence corroborating its safety. Therefore the present work aimed to evaluate the safety profile of myricetin derivative-rich fraction (MD) from S. malaccense leaf extract through single and repetitive oral administration in C57BL/6J mice. In the acute toxicity study mice were orally administered with MD at single doses of 25 150 500 and 1 500 mg/kg. Subsequently a modified sub-chronic toxicity assessment was performed by administering 150 mg/kg MD orally for 16 weeks. In both acute and sub-chronic toxicity studies there were no lethal effects and behavioural signs of toxicity observed. The body weight food and water intakes of mice were normal throughout the respective experimental periods. As compared to the respective control groups MD caused a significant improvement in serum uric acid and aspartate aminotransferase levels. The histopathological analysis of MD-administered mice did not show any inflammation or cell death. The MD-treated mice showed significantly reduced protein carbonyl and lipid hydroperoxide levels in urine liver and kidney tissues. Taken together the no-observed-adverse-effect level of MD was up to 1 500 mg/kg and considered safe for oral consumption over relatively long durations with oxidative stress attenuating properties.
Additional Metadata
Item Type: | Article |
---|---|
AGROVOC Term: | Mice |
AGROVOC Term: | Syzygium malaccensis |
AGROVOC Term: | Oxidative stress |
AGROVOC Term: | Experimental design |
AGROVOC Term: | Statistical analysis |
AGROVOC Term: | Analysis of variance |
AGROVOC Term: | Laboratory animals |
AGROVOC Term: | Body weight |
AGROVOC Term: | Food intake |
AGROVOC Term: | Safety |
Depositing User: | Mr. AFANDI ABDUL MALEK |
Last Modified: | 24 Apr 2025 00:55 |
URI: | http://webagris.upm.edu.my/id/eprint/10003 |
Actions (login required)
![]() |
View Item |