In-vitro validation of the use of jackfruit (Artocarpus heterophyllus lam) as an alternative for anthelmintic drugs for the control of parasitic nematodes in ruminants

Nik Him N. A. I. I., . and Ming Jiun J. L., . In-vitro validation of the use of jackfruit (Artocarpus heterophyllus lam) as an alternative for anthelmintic drugs for the control of parasitic nematodes in ruminants. pp. 17-25. ISSN 2180-3897

The aim of this study is to determine the phytochemical constituent of Artocarpus heterophyllus Lam (Jackfruit) and its effectiveness as an alternative for the anthelmintic treatment of parasitic nematodes in ruminants. Artocarpus heterophyllus Lam leaves were used to test on L3 nematode larva harvested from fecal culture. There are four species of parasitic nematodes identified namely: Haemonchus contortus Trichostrongylus sp. Cooperia sp. and Oesophagostomum sp. Haemonchus contortus was found to be the most dominant followed by Trichostrongylus sp. Cooperia sp. and Oesophagostomum sp. The phytochemical test of Artocarpus heterophyllus Lam leaves was revealed to possess alkaloids flavonoids tannins tripertenes and steroids. These components were shown to be effective at causing paralysis and deaths of parasitic nematode in the larval motility assay where 100 of the nematodes tested were killed below 6 hours at 5.0 mg/ml concentration; and inhibit migration in the larval migration assay where migration of the larva was completely inhibited in 2 hours using 2.0 mg/ml concentration. The results suggest that Artocarpus heterophyllus Lam leaves can be used as an alternative for the anthelmintic treatment in goats and sheep.

Full text available from: Official URL: https://myjurnal.mohe.gov.my/filebank/published_ar...

Abstract

The aim of this study is to determine the phytochemical constituent of Artocarpus heterophyllus Lam (Jackfruit) and its effectiveness as an alternative for the anthelmintic treatment of parasitic nematodes in ruminants. Artocarpus heterophyllus Lam leaves were used to test on L3 nematode larva harvested from fecal culture. There are four species of parasitic nematodes identified namely: Haemonchus contortus Trichostrongylus sp. Cooperia sp. and Oesophagostomum sp. Haemonchus contortus was found to be the most dominant followed by Trichostrongylus sp. Cooperia sp. and Oesophagostomum sp. The phytochemical test of Artocarpus heterophyllus Lam leaves was revealed to possess alkaloids flavonoids tannins tripertenes and steroids. These components were shown to be effective at causing paralysis and deaths of parasitic nematode in the larval motility assay where 100 of the nematodes tested were killed below 6 hours at 5.0 mg/ml concentration; and inhibit migration in the larval migration assay where migration of the larva was completely inhibited in 2 hours using 2.0 mg/ml concentration. The results suggest that Artocarpus heterophyllus Lam leaves can be used as an alternative for the anthelmintic treatment in goats and sheep.

[error in script]

Item Type:	Article
AGROVOC Term:	Jackfruit (tree)
AGROVOC Term:	Artocarpus heterophyllus
AGROVOC Term:	Ruminants
AGROVOC Term:	Leaf extracts
AGROVOC Term:	Plant parasitic nematodes
AGROVOC Term:	Alternative methods
AGROVOC Term:	Anthelmintics
AGROVOC Term:	In vitro experimentation
AGROVOC Term:	Disease treatment
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:55
URI:	http://webagris.upm.edu.my/id/eprint/10072

Actions (login required)

View Item