Formulation and antimicrobial screening of Piper sarmentosum cream against Staphylococcus aureus

Shamima Abdul Rahman, . and Ummi Salwani Abdullah, . and Shazreen Shaharuddin, . Formulation and antimicrobial screening of Piper sarmentosum cream against Staphylococcus aureus. pp. 527-540. ISSN 1511-3701

Piper sarmentosum known as kaduk has been traditionally used in different parts of the world to cure many diseases and ailments. It contains alkaloids and has been reported to possess many pharmacological properties like anti-cancer anti-hyperglycaemic anti-tuberculosis antioxidant and antimalarial. This study aimed to evaluate the formulation of P. sarmentosum cream and exploring the antimicrobial properties in different types of cream formulation before in vivo study. The leaves extract of P. sarmentosum was obtained from the cold-soaked methanolic extraction method evaporated and dried to produce the powdered extract. Then it was diluted into four different concentrations 25 w/v 50 w/v 75 w/v and 100 w/v for Staphylococcus aureus antimicrobial screening. Based on the S. aureus antimicrobial screening four types of creams were formulated (Cream A: cream base without Piper sarmentosum extract; Cream B: Piper sarmentosum extract (5) only; Cream C: Piper sarmentosum extract (5) with parabens preservatives; Cream D: Piper sarmentosum extract (5) with vitamin E) and evaluated for their physical appearance pH stability study and antimicrobial activity against S. aureus. As a result 100 w/v concentration of the P. sarmentosum extract showed the highest result in the zone of inhibition (5.50 mm 0.03) towards S. aureus and was selected for cream formulation. In evaluating their physical appearance all formulated creams showed high homogeneity and consistency with no phase separation and pH between 7.2 “ 8.0 0.07. On stability study all creams with three different temperatures of 4C 27C and 37C for 30 days show no colour changes high homogeneity and consistency with any phase separation. The results of antimicrobial screening for all formulated creams show that Cream D has the highest zone of inhibition towards S. aureus (5.53 mm 0.25) followed by Cream C (4.43 mm 0.13). In conclusion P. sarmentosum cream formulation showed high stability properties and possessed anti-microbial properties suggesting its potentials for wound healing cream.

Full text available from: Official URL: http://www.pertanika.upm.edu.my/pjtas/browse/regul...

Abstract

Piper sarmentosum known as kaduk has been traditionally used in different parts of the world to cure many diseases and ailments. It contains alkaloids and has been reported to possess many pharmacological properties like anti-cancer anti-hyperglycaemic anti-tuberculosis antioxidant and antimalarial. This study aimed to evaluate the formulation of P. sarmentosum cream and exploring the antimicrobial properties in different types of cream formulation before in vivo study. The leaves extract of P. sarmentosum was obtained from the cold-soaked methanolic extraction method evaporated and dried to produce the powdered extract. Then it was diluted into four different concentrations 25 w/v 50 w/v 75 w/v and 100 w/v for Staphylococcus aureus antimicrobial screening. Based on the S. aureus antimicrobial screening four types of creams were formulated (Cream A: cream base without Piper sarmentosum extract; Cream B: Piper sarmentosum extract (5) only; Cream C: Piper sarmentosum extract (5) with parabens preservatives; Cream D: Piper sarmentosum extract (5) with vitamin E) and evaluated for their physical appearance pH stability study and antimicrobial activity against S. aureus. As a result 100 w/v concentration of the P. sarmentosum extract showed the highest result in the zone of inhibition (5.50 mm 0.03) towards S. aureus and was selected for cream formulation. In evaluating their physical appearance all formulated creams showed high homogeneity and consistency with no phase separation and pH between 7.2 “ 8.0 0.07. On stability study all creams with three different temperatures of 4C 27C and 37C for 30 days show no colour changes high homogeneity and consistency with any phase separation. The results of antimicrobial screening for all formulated creams show that Cream D has the highest zone of inhibition towards S. aureus (5.53 mm 0.25) followed by Cream C (4.43 mm 0.13). In conclusion P. sarmentosum cream formulation showed high stability properties and possessed anti-microbial properties suggesting its potentials for wound healing cream.

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Item Type:	Article
AGROVOC Term:	Formulations
AGROVOC Term:	Antimicrobials
AGROVOC Term:	Staphylococcus aureus
AGROVOC Term:	Medicinal plants
AGROVOC Term:	Sampling
AGROVOC Term:	Statistical analysis
AGROVOC Term:	Traditional medicines
AGROVOC Term:	Phytotherapy
AGROVOC Term:	Natural resources
AGROVOC Term:	methanolic extraction
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:55
URI:	http://webagris.upm.edu.my/id/eprint/10138

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