Clitoria ternatea ethanolic extract prevents dental caries via inhibiting Streptococcus mutans growth and quorum sensing

Yanti., . and Setiawan T., . and Lay B. W., . Clitoria ternatea ethanolic extract prevents dental caries via inhibiting Streptococcus mutans growth and quorum sensing. pp. 492-497. ISSN 2550-2166

Our previous study demonstrated that the blue butterfly pea flower (Clitoria ternatea) had several pharmacological effects to treat inflammatory-related diseases including edema and diabetes. However its benefit for preventing dental caries and protecting the tooth has not been explored yet. Here we investigated whether C. ternatea ethanolic extract (CTEE) prevented dental caries through antibacterial and antiquorum sensing activities toward oral pathogen Streptococcus mutans in vitro. CTEE was made by using kinetic maceration in ethanol. Antibacterial activity of CTEE against S. mutans was tested using disk diffusion agar and microdilution assays. Quorum sensing system employed Chromobacterium violaceum bacteria to produce violacein and CTEE at various concentrations was tested for its antiquorum sensing activity to inhibit the violacein production. Our results demonstrated that CTEE at 1 mg/mL showed a significant inhibition 90 against S. mutans indicating its MIC value. For the quorum sensing system CTEE at the lowest concentration (0.25 mg/mL) significantly inhibit up to 68 of violacein produced by C. violaceum. These data indicate that CTEE may act as a natural oral functional food with antibacterial and antiquorum sensing activities for the prevention of dental caries.

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Abstract

Our previous study demonstrated that the blue butterfly pea flower (Clitoria ternatea) had several pharmacological effects to treat inflammatory-related diseases including edema and diabetes. However its benefit for preventing dental caries and protecting the tooth has not been explored yet. Here we investigated whether C. ternatea ethanolic extract (CTEE) prevented dental caries through antibacterial and antiquorum sensing activities toward oral pathogen Streptococcus mutans in vitro. CTEE was made by using kinetic maceration in ethanol. Antibacterial activity of CTEE against S. mutans was tested using disk diffusion agar and microdilution assays. Quorum sensing system employed Chromobacterium violaceum bacteria to produce violacein and CTEE at various concentrations was tested for its antiquorum sensing activity to inhibit the violacein production. Our results demonstrated that CTEE at 1 mg/mL showed a significant inhibition 90 against S. mutans indicating its MIC value. For the quorum sensing system CTEE at the lowest concentration (0.25 mg/mL) significantly inhibit up to 68 of violacein produced by C. violaceum. These data indicate that CTEE may act as a natural oral functional food with antibacterial and antiquorum sensing activities for the prevention of dental caries.

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Item Type:	Article
AGROVOC Term:	Clitoria ternatea
AGROVOC Term:	Flowers
AGROVOC Term:	Fabaceae
AGROVOC Term:	Antibacterial properties
AGROVOC Term:	Dental caries
AGROVOC Term:	Streptococcus mutans
AGROVOC Term:	Functional foods
AGROVOC Term:	Culinary herbs
AGROVOC Term:	Flower extracts
AGROVOC Term:	Health care
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:55
URI:	http://webagris.upm.edu.my/id/eprint/10437

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