The elastic recovery ejection work strength and dissolution of instant coffee tablet containing croscarmellose sodium disintegrant

M. S. Anuar, . and N. S. Mohd Rosidi, . and S. M. Tahir, . The elastic recovery ejection work strength and dissolution of instant coffee tablet containing croscarmellose sodium disintegrant. pp. 14-18. ISSN 0128-7702

Croscarmellose sodium disintegrant agent commonly used in the pharmaceutical tablet formulation was employed in the instant coffee tablet formulation. Various compositions of croscarmellose sodium were added to the instant coffee tablet formulation; 20 w/w 40 w/w 60 w/w and 80 w/w respectively. These mixtures were then compacted through the uniaxial die compaction process forming 1 g tablets having 13 mm diameters each at various compaction pressures of 37.7 MPa 75.4 MPa 113.0 MPa and 150.7 MPa. The ejection work done when ejecting the tablet from the die was calculated to represent the frictional resistance to tablet motion during ejection. The tablet elastic recovery was measured as a quantitative measure of the tablet physical dimensional stability. Meanwhile the mechanical strength as well as the tablet dissolution were also measured. The results showed that the croscarmellose composition and the compaction pressure affected all the studied tabletting properties. Generally croscarmellose sodium increased the tablet elastic recovery and lowered the tablet ejection work tensile strength and dissolution time in experimental conditions employed in this work. However the extent of the croscarmellose sodium influence was clearly dependent upon the compaction pressures used for instant coffee tablet formation.

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Abstract

Croscarmellose sodium disintegrant agent commonly used in the pharmaceutical tablet formulation was employed in the instant coffee tablet formulation. Various compositions of croscarmellose sodium were added to the instant coffee tablet formulation; 20 w/w 40 w/w 60 w/w and 80 w/w respectively. These mixtures were then compacted through the uniaxial die compaction process forming 1 g tablets having 13 mm diameters each at various compaction pressures of 37.7 MPa 75.4 MPa 113.0 MPa and 150.7 MPa. The ejection work done when ejecting the tablet from the die was calculated to represent the frictional resistance to tablet motion during ejection. The tablet elastic recovery was measured as a quantitative measure of the tablet physical dimensional stability. Meanwhile the mechanical strength as well as the tablet dissolution were also measured. The results showed that the croscarmellose composition and the compaction pressure affected all the studied tabletting properties. Generally croscarmellose sodium increased the tablet elastic recovery and lowered the tablet ejection work tensile strength and dissolution time in experimental conditions employed in this work. However the extent of the croscarmellose sodium influence was clearly dependent upon the compaction pressures used for instant coffee tablet formation.

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Item Type:	Article
AGROVOC Term:	Instant coffee
AGROVOC Term:	Dissolution
AGROVOC Term:	Tabletting
AGROVOC Term:	Sampling
AGROVOC Term:	Experiments
AGROVOC Term:	Data collection
AGROVOC Term:	Food industry
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:55
URI:	http://webagris.upm.edu.my/id/eprint/10540

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