Multivariate analysis on the relationship between radical scavenging activities and phenolic compounds of baijiu and its protective effect against LPS-induced inflammation in THP-1 cells

Chen L., . and Hong J., . and Zhao D., . and Sun J., . Multivariate analysis on the relationship between radical scavenging activities and phenolic compounds of baijiu and its protective effect against LPS-induced inflammation in THP-1 cells. pp. 116-127. ISSN 22317546

In previous studies three phenolic compounds (vanillin 4-methylguaiacol and 4-ethylguaiacol) were identified in baijiu and confirmed to possess antioxidant activity in vitro. However the distribution of phenolic compounds in baijiu and their associations with the functionality of this regimen have not been previously reported. In the present work the antioxidant capacity and anti-inflammatory effect of baijiu were evaluated by DPPH ABTS� ELISA and real-time PCR assays. The concentrations of vanillin 4-methylguaiacol and 4-ethylguaiacol (bioactive phenolic compounds) in 103 baijiu samples were confirmed by liquid-liquid extraction (LLE) combined with gas chromatography-mass spectrometry (GC-MS). Baijiu exhibited DPPH and ABTS� scavenging activities which positively correlated with the concentrations of vanillin 4-methylguaiacol and 4-ethylguaiacol. Moreover ELISA and real-time PCR assays demonstrated that baijiu could relieve inflammation caused by LPS through the inhibition of NF-B and AP-1 expressions induction of Nrf2 expression and repression of inflammatory cytokine secretion. These findings lay the foundation for further investigation on the health benefits of baijiu and its bioactive components by animal and human studies.

Full text available from: Official URL: http://www.ifrj.upm.edu.my/29%20(01)%202022/DONE%2...

Abstract

In previous studies three phenolic compounds (vanillin 4-methylguaiacol and 4-ethylguaiacol) were identified in baijiu and confirmed to possess antioxidant activity in vitro. However the distribution of phenolic compounds in baijiu and their associations with the functionality of this regimen have not been previously reported. In the present work the antioxidant capacity and anti-inflammatory effect of baijiu were evaluated by DPPH ABTS� ELISA and real-time PCR assays. The concentrations of vanillin 4-methylguaiacol and 4-ethylguaiacol (bioactive phenolic compounds) in 103 baijiu samples were confirmed by liquid-liquid extraction (LLE) combined with gas chromatography-mass spectrometry (GC-MS). Baijiu exhibited DPPH and ABTS� scavenging activities which positively correlated with the concentrations of vanillin 4-methylguaiacol and 4-ethylguaiacol. Moreover ELISA and real-time PCR assays demonstrated that baijiu could relieve inflammation caused by LPS through the inhibition of NF-B and AP-1 expressions induction of Nrf2 expression and repression of inflammatory cytokine secretion. These findings lay the foundation for further investigation on the health benefits of baijiu and its bioactive components by animal and human studies.

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Item Type:	Article
AGROVOC Term:	White wines
AGROVOC Term:	Distilled spirits
AGROVOC Term:	Alcoholic fermentation
AGROVOC Term:	Grain sorghum
AGROVOC Term:	Multivariate analysis
AGROVOC Term:	Antiinflammatory agents
AGROVOC Term:	Phenolic compounds
AGROVOC Term:	Antioxidants
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:55
URI:	http://webagris.upm.edu.my/id/eprint/10623

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