Impact of tartrazine and curcumin on mineral status and thyroid and reproductive hormones disruption in vivo

Bekhit A. E. D. A., . and A. Ismail, . and Shakoor S., . and Zia Ur Rahman, . and M. R. Sabran, . and Roohinejad S., . Impact of tartrazine and curcumin on mineral status and thyroid and reproductive hormones disruption in vivo. pp. 186-199. ISSN 22317546

Endocrine disrupters (EDCs) are naturally occurring or man-made substances that either mimic or obstruct the functions of oestrogens and androgens thyroid hormones as well as microminerals in the body. The present work aimed to evaluate the effects of oral administration of tartrazine and curcumin synthetic and natural dyes respectively on thyroid hormones (T‚ T‚„ and TSH) female reproductive hormones (oestrogen progesterone LH and FSH) and minerals (iron copper zinc sodium potassium and chloride) in plasma liver and kidney of female rats after 15 30 and 45 d of treatment. The rats were treated with admissible daily intake (ADI) and 10 ADI (9.6 and 96 mg/kg/body weight for tartrazine 3.85 and 38.5 mg/kg/body weight for curcumin respectively). Results showed significant changes in thyroid and female reproductive hormones especially in the tartrazine-treated groups as compared to the control. Low and high doses of tartrazine and curcumin significantly (p 0.05) decreased iron copper and zinc concentrations in plasma whereas the concentrations of sodium and copper in liver and kidney increased. Both tartrazine and curcumin at ADI and 10 ADI resulted in lower LH levels after 30 and 45 d of treatment. After 30 d low and high dose of tartrazine significantly decreased T‚„ oestrogen and FSH levels; whereas progesterone level increased. The results demonstrated that hormone secretion and mineral content in tissues are severely affected at ADI and higher concentrations of tartrazine and curcumin. These observations suggested that lower doses of these dyes might be a safer option for their usage in foods and pharmaceuticals.

Full text available from: Official URL: http://www.ifrj.upm.edu.my/29%20(01)%202022/DONE%2...

Abstract

Endocrine disrupters (EDCs) are naturally occurring or man-made substances that either mimic or obstruct the functions of oestrogens and androgens thyroid hormones as well as microminerals in the body. The present work aimed to evaluate the effects of oral administration of tartrazine and curcumin synthetic and natural dyes respectively on thyroid hormones (T‚ T‚„ and TSH) female reproductive hormones (oestrogen progesterone LH and FSH) and minerals (iron copper zinc sodium potassium and chloride) in plasma liver and kidney of female rats after 15 30 and 45 d of treatment. The rats were treated with admissible daily intake (ADI) and 10 ADI (9.6 and 96 mg/kg/body weight for tartrazine 3.85 and 38.5 mg/kg/body weight for curcumin respectively). Results showed significant changes in thyroid and female reproductive hormones especially in the tartrazine-treated groups as compared to the control. Low and high doses of tartrazine and curcumin significantly (p 0.05) decreased iron copper and zinc concentrations in plasma whereas the concentrations of sodium and copper in liver and kidney increased. Both tartrazine and curcumin at ADI and 10 ADI resulted in lower LH levels after 30 and 45 d of treatment. After 30 d low and high dose of tartrazine significantly decreased T‚„ oestrogen and FSH levels; whereas progesterone level increased. The results demonstrated that hormone secretion and mineral content in tissues are severely affected at ADI and higher concentrations of tartrazine and curcumin. These observations suggested that lower doses of these dyes might be a safer option for their usage in foods and pharmaceuticals.

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Item Type:	Article
AGROVOC Term:	Food colorants
AGROVOC Term:	Tartrazine
AGROVOC Term:	Curcumin
AGROVOC Term:	In vivo experimentation
AGROVOC Term:	Tissue
AGROVOC Term:	Thyroid hormones
AGROVOC Term:	Oxidative stress
AGROVOC Term:	Minerals
AGROVOC Term:	Reproductive performance
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:55
URI:	http://webagris.upm.edu.my/id/eprint/10628

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