Ginger constituents ameliorated B()P-induced toxicity via modulation of antioxidants and xenobiotic-metabolising enzymes in mice

Li F., . and Ren Y., . and Gao Z., . and Wang Y., . and Liu B., . and Ma R., . and Li D., . Ginger constituents ameliorated B()P-induced toxicity via modulation of antioxidants and xenobiotic-metabolising enzymes in mice. pp. 433-445. ISSN 22317546

Accumulating evidence has linked benzo()pyrene (BP) exposure to carcinogenesis with severe damages to reproductive hematopoietic hepatic and renal tissues. Ginger (Zingiber officinale Roscoe) rhizome consumed worldwide as a spice and herbal medicine exhibits a variety of health benefits including antioxidant anti-inflammatory and anti-cancer activities. In the present work the efficacy of three ginger compounds namely 6-gingerol zingerone and curcumin against BP-induced toxicity in mice was investigated. Kunming Swiss albino male mice were orally gavage with curcumin 6-gingerol or zingerone (all at a dose of 100mg/kg body weight) for two weeks before intraperitoneal injection with benzo()pyrene (BP) at 20 mg/kg body weight. The effect of these ginger compounds on antioxidant and xenobiotic-metabolising enzymes in vivo was investigated. Results showed that pre-treatment with curcumin 6-gingerol or zingerone significantly (p 0.05) increased catalase (CAT) and glutathione peroxidase (GPx) activities in serum and liver of mice upregulated activities of phase II enzymes (quinone reductase (QR) and glutathione-S-transferase (GST)) and their protein and mRNA levels in liver of mice; but reduced levels of activities protein and mRNA of phase I enzymes (CYP1A1 and CYP1A2) as compared to those of BP-only treatment. Furthermore these compounds significantly (p 0.05) stimulated nuclear factor erythroid 2-related factor 2 (Nrf2) protein expression whilst curcumin suppressed the expression of Kelch-like ECH-associated protein 1 (Keap1) in liver. These results could contribute to our understanding of the potential beneficial effects of consuming ginger as food and/or dietary supplement.

Full text available from: Official URL: http://www.ifrj.upm.edu.my/29%20(02)%202022/20%20-...

Abstract

Accumulating evidence has linked benzo()pyrene (BP) exposure to carcinogenesis with severe damages to reproductive hematopoietic hepatic and renal tissues. Ginger (Zingiber officinale Roscoe) rhizome consumed worldwide as a spice and herbal medicine exhibits a variety of health benefits including antioxidant anti-inflammatory and anti-cancer activities. In the present work the efficacy of three ginger compounds namely 6-gingerol zingerone and curcumin against BP-induced toxicity in mice was investigated. Kunming Swiss albino male mice were orally gavage with curcumin 6-gingerol or zingerone (all at a dose of 100mg/kg body weight) for two weeks before intraperitoneal injection with benzo()pyrene (BP) at 20 mg/kg body weight. The effect of these ginger compounds on antioxidant and xenobiotic-metabolising enzymes in vivo was investigated. Results showed that pre-treatment with curcumin 6-gingerol or zingerone significantly (p 0.05) increased catalase (CAT) and glutathione peroxidase (GPx) activities in serum and liver of mice upregulated activities of phase II enzymes (quinone reductase (QR) and glutathione-S-transferase (GST)) and their protein and mRNA levels in liver of mice; but reduced levels of activities protein and mRNA of phase I enzymes (CYP1A1 and CYP1A2) as compared to those of BP-only treatment. Furthermore these compounds significantly (p 0.05) stimulated nuclear factor erythroid 2-related factor 2 (Nrf2) protein expression whilst curcumin suppressed the expression of Kelch-like ECH-associated protein 1 (Keap1) in liver. These results could contribute to our understanding of the potential beneficial effects of consuming ginger as food and/or dietary supplement.

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Item Type:	Article
AGROVOC Term:	Ginger
AGROVOC Term:	Zingiber officinale
AGROVOC Term:	Rhizomes
AGROVOC Term:	Benzopyrene
AGROVOC Term:	Antioxidants
AGROVOC Term:	Xenobiotic metabolism
AGROVOC Term:	Food consumption
AGROVOC Term:	Dietary components
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:55
URI:	http://webagris.upm.edu.my/id/eprint/10647

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