Citation
Lim Y. M., . and M. N. H. Lajis, . and Jasril M, . and Ghafar, . and Habsah M, . and Nakatani N., . and Amran M, . and Ali A. M., . and Kikuzaki H., . and Rahman A. A., . (2000) Antitumour promoting and antioxidant activities of Malaysian species in the family Zingiberaceae. [Proceedings Paper]
Abstract
The negative perceptions of synthetic products and the reluctance of their usage by consumers have boosted the potential of developing commercial products from natural sources. The current trend as well as the availability of various Zingiberaceous species at PSGT UPM has prompted us to find new and potentially valuable natural antioxidants. To evaluate their antioxidant activity a total of 30 species from the genera Alpinia Costus Zingiber Hedychium Hornstedtia Achasma Nicolaia Curcuma Etlingera Amomum and Elettariopsis were screened using the FTC method. All species except Curcuma occorhiza exhibited higher activity than the known natural antioxidant atocopherol. Twenty-seven samples consisting of 18 CH2CI2 extracts and nine MeOH extracts were also tested for in vitro antitumour promoting activity using EBV-EA Epstain-Barr virus-early antigen activation assay. Fourty-four percent of the CH2CI2 extracts and 33 of MeOH extracts from the species tested were highly active at a concentration of 20 g/ml. This implied the inhibition of cellular oxidation that was linked to pathological incidents such as heart disease aging and cancer. The antioxidant and anti tumour promoting activities observed in these extracts are particularly relevant since they are used as major ingredients in the preparation of jamu and traditional ointments.
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Abstract
The negative perceptions of synthetic products and the reluctance of their usage by consumers have boosted the potential of developing commercial products from natural sources. The current trend as well as the availability of various Zingiberaceous species at PSGT UPM has prompted us to find new and potentially valuable natural antioxidants. To evaluate their antioxidant activity a total of 30 species from the genera Alpinia Costus Zingiber Hedychium Hornstedtia Achasma Nicolaia Curcuma Etlingera Amomum and Elettariopsis were screened using the FTC method. All species except Curcuma occorhiza exhibited higher activity than the known natural antioxidant atocopherol. Twenty-seven samples consisting of 18 CH2CI2 extracts and nine MeOH extracts were also tested for in vitro antitumour promoting activity using EBV-EA Epstain-Barr virus-early antigen activation assay. Fourty-four percent of the CH2CI2 extracts and 33 of MeOH extracts from the species tested were highly active at a concentration of 20 g/ml. This implied the inhibition of cellular oxidation that was linked to pathological incidents such as heart disease aging and cancer. The antioxidant and anti tumour promoting activities observed in these extracts are particularly relevant since they are used as major ingredients in the preparation of jamu and traditional ointments.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. mal QK99 A1S471 2000 Call Number. |
| AGROVOC Term: | ANTIOXIDANTS |
| AGROVOC Term: | SPECIES |
| AGROVOC Term: | ZINGIBERACEAE |
| AGROVOC Term: | TRADITIONAL MEDICINES |
| AGROVOC Term: | MALAYSIA |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:13 |
| URI: | http://webagris.upm.edu.my/id/eprint/11312 |
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