Citation
Hamdan N., . and Chee B. J., . and Umi Kalsom Y., . and Zolkepli O., . (2000) The hypoglycaemic effect of Mengkudu Morinda citrifolia. [Proceedings Paper]
Abstract
In the Pacific region mengkudu Morinda citrifolia is a wild growing plant reputed for countless medicinal values. The ripe fruit of mengkudu was traditionally used in Malaysia and Indonesia for the treatment of diabetes mellitus. The purpose of this study is to verify the potential hypoglycaemic property of the aqueous extract of M. citrifolia. Freeze-dried extracts 3 30 and 300 mg/kg were tested on streptozotocin induced Type 2 Diabetic rats in an Oral Glucose Tolerance Test OGTT. The extract treatment of 300 mg/kg demonstrated hypoglycaemic property by significantly lowered the value of the blood glucose level measured as the area under the OGTT curve 4370.71 99.13 mg/min six weeks after extract administration. The rate of glucose clearance amongst the extract treated rats was also found to be the fastest 1.07 mg/min and statistically significant compared to the control as observed in the eighth week of extract administration. The aqueous extract therefore had demonstrated a substantial effect in lowering the blood glucose level in diabetic rats and has a potential as a hypoglycaemic agent. However more investigation is required to further explore this possibility.
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Abstract
In the Pacific region mengkudu Morinda citrifolia is a wild growing plant reputed for countless medicinal values. The ripe fruit of mengkudu was traditionally used in Malaysia and Indonesia for the treatment of diabetes mellitus. The purpose of this study is to verify the potential hypoglycaemic property of the aqueous extract of M. citrifolia. Freeze-dried extracts 3 30 and 300 mg/kg were tested on streptozotocin induced Type 2 Diabetic rats in an Oral Glucose Tolerance Test OGTT. The extract treatment of 300 mg/kg demonstrated hypoglycaemic property by significantly lowered the value of the blood glucose level measured as the area under the OGTT curve 4370.71 99.13 mg/min six weeks after extract administration. The rate of glucose clearance amongst the extract treated rats was also found to be the fastest 1.07 mg/min and statistically significant compared to the control as observed in the eighth week of extract administration. The aqueous extract therefore had demonstrated a substantial effect in lowering the blood glucose level in diabetic rats and has a potential as a hypoglycaemic agent. However more investigation is required to further explore this possibility.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. mal QK99 A1S471 2000 Call Number. |
| AGROVOC Term: | HYPOGLYCAEMIA |
| AGROVOC Term: | MORINDA CITRIFOLIA |
| AGROVOC Term: | RATS |
| AGROVOC Term: | DIABETES |
| AGROVOC Term: | MALAYSIA |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:14 |
| URI: | http://webagris.upm.edu.my/id/eprint/11314 |
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