Study of different sample preparation methods for the detection of heavy metals in locally available traditional medicines

Mohd Asri M.N., . and Siti Nurfairuz M. F., . and Helal Uddin A. B. M., . and Mohamad Shahreen A., . and Saeed M., . (2009) Study of different sample preparation methods for the detection of heavy metals in locally available traditional medicines. [Proceedings Paper]

Traditional medicines have been used for many years for prevention and treatment of diseases throughout the world. Problems and difficulties arise in the quality assurance of traditional medicinal products due to the many unidentified chemical entities as well as the actual active components in the finished products. Heavy metal toxicity in traditional medicines is very common and often causes serious problems to the patient. In Malaysia all traditional medicines in the market must be registered with the National Pharmaceutical Control Bureau NPCB. Being within the permitted limit of a selected range of heavy metals is one of the major criteria for the registration.Present study shows the comparison of different sample preparation method for metal ion detection in traditional medicines using flame atomic absorption spectroscopy technique FAAS. Hollow cathode lamp was used as a radiation source and air acetylene mixture was used for the flame. The wavelength for lead and cadmium were 283.3 and 228.8 respectively. Sample preparation steps involved acid digestion of the samples using two different digestion methods namely nitric-hydrochloric acid and nitric-perchloric acid digestion. Twenty three traditional medicine samples used as a cure for different illness were analysed for the presence of lead and cadmium. Of the two digestion processes nitric-perchloric acid digestion process showed better result than nitric-hydrochloric acid digestion method. Four of them showed absence of lead and six showed absence of cadmium in both digestion systems.

Full text available from:

Abstract

Traditional medicines have been used for many years for prevention and treatment of diseases throughout the world. Problems and difficulties arise in the quality assurance of traditional medicinal products due to the many unidentified chemical entities as well as the actual active components in the finished products. Heavy metal toxicity in traditional medicines is very common and often causes serious problems to the patient. In Malaysia all traditional medicines in the market must be registered with the National Pharmaceutical Control Bureau NPCB. Being within the permitted limit of a selected range of heavy metals is one of the major criteria for the registration.Present study shows the comparison of different sample preparation method for metal ion detection in traditional medicines using flame atomic absorption spectroscopy technique FAAS. Hollow cathode lamp was used as a radiation source and air acetylene mixture was used for the flame. The wavelength for lead and cadmium were 283.3 and 228.8 respectively. Sample preparation steps involved acid digestion of the samples using two different digestion methods namely nitric-hydrochloric acid and nitric-perchloric acid digestion. Twenty three traditional medicine samples used as a cure for different illness were analysed for the presence of lead and cadmium. Of the two digestion processes nitric-perchloric acid digestion process showed better result than nitric-hydrochloric acid digestion method. Four of them showed absence of lead and six showed absence of cadmium in both digestion systems.

[error in script]

Item Type:	Proceedings Paper
Additional Information:	Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. mal QK99 M3S471 2008 Call Number
AGROVOC Term:	TRADITIONAL MEDICINES
AGROVOC Term:	ACIDS
AGROVOC Term:	DIGESTION
AGROVOC Term:	HEAVY METALS
AGROVOC Term:	MALAYSIA
Geographical Term:	MALAYSIA
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 05:14
URI:	http://webagris.upm.edu.my/id/eprint/11355

Actions (login required)

View Item