Pharmacological evidence for the activation of peripheral ATP-sensitive K channels by methanol extract of Mitragyna speciosa Korth in formalin test

Md. Lip J., . and Syamimi K., . and Wan Mastura S M., . and Mohd Roslan S., . and Azyyati M P., . and Mohamad Taufik H B., . (2009) Pharmacological evidence for the activation of peripheral ATP-sensitive K channels by methanol extract of Mitragyna speciosa Korth in formalin test. [Proceedings Paper]

The possible activation of the peripheral ATP-sensitive K channels by Mitragyna speciosa Korth methanolic extract MSME was assessed in the rat 1 formalin test. MSME given by intraperitoneal route produced significant P0.05 dose-dependent anti-nociception in the first and the second phase of the test. However local pre-treatment of the paw with glibenclamide an ATP-sensitive K channel inhibitors tetraethylammonium blockers of voltage-dependent K channel and apamin inhibitor of small-conductance Ca2-activated K channel significantly reversed the MSME-induced antinociception. These results suggest that the anti-nociceptive effect of MSME is mediated by the activation of ATP-sensitive K channels in addition to the opening of small-conductance Ca2-activated K channels at peripheral afferent neurons.

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Abstract

The possible activation of the peripheral ATP-sensitive K channels by Mitragyna speciosa Korth methanolic extract MSME was assessed in the rat 1 formalin test. MSME given by intraperitoneal route produced significant P0.05 dose-dependent anti-nociception in the first and the second phase of the test. However local pre-treatment of the paw with glibenclamide an ATP-sensitive K channel inhibitors tetraethylammonium blockers of voltage-dependent K channel and apamin inhibitor of small-conductance Ca2-activated K channel significantly reversed the MSME-induced antinociception. These results suggest that the anti-nociceptive effect of MSME is mediated by the activation of ATP-sensitive K channels in addition to the opening of small-conductance Ca2-activated K channels at peripheral afferent neurons.

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Item Type:	Proceedings Paper
Additional Information:	Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. mal QK99 M3S471 2008 Call Number
AGROVOC Term:	PHARMACOLOGY
AGROVOC Term:	METHANOL
AGROVOC Term:	EXTRACTS
AGROVOC Term:	RUBIACEAE
AGROVOC Term:	MALAYSIA
Geographical Term:	MALAYSIA
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 05:14
URI:	http://webagris.upm.edu.my/id/eprint/11369

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