Citation
Hani Idayu B., . and Fadzureena J., . and Mazura M P., . and Nuziah H., . and Nik Musa`adah M., . and Kaveena K., . (2009) Anti-inflammatory evaluation of the leaf extracts of Senna occidentalis Linn. [Proceedings Paper]
Abstract
Senna occidentalis L. Link from the family Fabaceae a small shrub locally known as kachang kota is used in traditionaL medicine against fevers. tuberculosis anaemia liver complaints and as a reconstituent for general weakness and illness. In this study various extracts from the leaves of S. occidentalis were evaluated for therapeutic potential as anti-inflammatory agents. The anti-inflammatory activity was tested using the hyaluronidase lipoxygenase xanthine oxidase assays and also an animal model of 12-0-tetradecanoylphorbol-13-acetate TPA-induced ear oedema. All thc extracts showed some degree of inhibitions against all the enzymes. The most significant activity was found to be in ethyl acetate and dichloromethane extracts which gave 100 and 99 inhibition at 100 ug/ml against enzyme lipoxygenase 100 and hyaluronidase respectively. The hexane extract also demonstrated profound activity in both assays while the ethyl acetate extract was the only one found to be effective in the xanthine oxidase assay with inhibition of 76. In the TPA-induced ear oedema model low to moderate activity was observed for all the extracts with the dichloromethane extract being the most active with inhibition of 73 at a concentration of 2 mg/ear. This study provides a scientific basis for the use of this plant for the treatment of inflammation-related illnesses.
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Abstract
Senna occidentalis L. Link from the family Fabaceae a small shrub locally known as kachang kota is used in traditionaL medicine against fevers. tuberculosis anaemia liver complaints and as a reconstituent for general weakness and illness. In this study various extracts from the leaves of S. occidentalis were evaluated for therapeutic potential as anti-inflammatory agents. The anti-inflammatory activity was tested using the hyaluronidase lipoxygenase xanthine oxidase assays and also an animal model of 12-0-tetradecanoylphorbol-13-acetate TPA-induced ear oedema. All thc extracts showed some degree of inhibitions against all the enzymes. The most significant activity was found to be in ethyl acetate and dichloromethane extracts which gave 100 and 99 inhibition at 100 ug/ml against enzyme lipoxygenase 100 and hyaluronidase respectively. The hexane extract also demonstrated profound activity in both assays while the ethyl acetate extract was the only one found to be effective in the xanthine oxidase assay with inhibition of 76. In the TPA-induced ear oedema model low to moderate activity was observed for all the extracts with the dichloromethane extract being the most active with inhibition of 73 at a concentration of 2 mg/ear. This study provides a scientific basis for the use of this plant for the treatment of inflammation-related illnesses.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. mal QK99 M3S471 2008 Call Number |
| AGROVOC Term: | LEGUMINOSAE |
| AGROVOC Term: | EXTRACTS |
| AGROVOC Term: | TRADITIONAL MEDICINES |
| AGROVOC Term: | FRACTIONATION |
| AGROVOC Term: | CASSIA OCCIDENTALIS |
| AGROVOC Term: | MALAYSIA |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:14 |
| URI: | http://webagris.upm.edu.my/id/eprint/11371 |
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