Acute and sub-chronic toxicity study of Fucus deltoidea in diabetic rats

Wong T W, . and Ilyanie H Y., . and Choo C Y., . (2009) Acute and sub-chronic toxicity study of Fucus deltoidea in diabetic rats. [Proceedings Paper]

Ficus delta idea Jack Moraceae locally known as mas cotek or Serapat angin has been widely utilized in Malaysia for various medicinal purposes including the treatment of diabetes mellitus. An increase in the popularity of its use entails scientific evaluation on safety. This study evaluated both acute and sub-chronic toxicity profiles of methanol extract isolated from the leaves of F. deltoidea in streptozotocin-induced diabetic rats. The rats n 5/group were subjected to acclimatization for 7 days and fasted for 15 h prior to experiments. The acute toxicity evaluation proceeded through administering orally to the rats methanol extract ranging from 1600 to 6400 mg/kg body weight of rat in 10 w/v Tween 80. The extract-fed rats were subjected to macroscopic observation at 6 12 24. 48 and 72 h for Overt signs of acute toxicity and death. The sub-chronic toxicity test was conducted by administering orally 200 mg methanol extract/kg body weight to rats once daily for 28 days. These rats were examined weekly for symptoms of toxicity food and water consumption pattern body weight and profiles of urination and defecation as well as their biochemical and histological profiles of liver and kidney at the end of 28 days. There were no Overt signs and death among control and extract-fed rats in acute toxicity study. The sub-chronic administration of rats with methanol extract did not bring about marked changes in the behavior body weight food and water intake urination and defecation pattern biochemical. parameters urea bilirubin creatinine alanine aminotransferase and aspartate aminotransferaseas well as histological profiles of rats when compared to the control. The methanol extract of F deltoidea was considered as at least non-toxic for consumption by the diabetic rats via the oral route.

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Abstract

Ficus delta idea Jack Moraceae locally known as mas cotek or Serapat angin has been widely utilized in Malaysia for various medicinal purposes including the treatment of diabetes mellitus. An increase in the popularity of its use entails scientific evaluation on safety. This study evaluated both acute and sub-chronic toxicity profiles of methanol extract isolated from the leaves of F. deltoidea in streptozotocin-induced diabetic rats. The rats n 5/group were subjected to acclimatization for 7 days and fasted for 15 h prior to experiments. The acute toxicity evaluation proceeded through administering orally to the rats methanol extract ranging from 1600 to 6400 mg/kg body weight of rat in 10 w/v Tween 80. The extract-fed rats were subjected to macroscopic observation at 6 12 24. 48 and 72 h for Overt signs of acute toxicity and death. The sub-chronic toxicity test was conducted by administering orally 200 mg methanol extract/kg body weight to rats once daily for 28 days. These rats were examined weekly for symptoms of toxicity food and water consumption pattern body weight and profiles of urination and defecation as well as their biochemical and histological profiles of liver and kidney at the end of 28 days. There were no Overt signs and death among control and extract-fed rats in acute toxicity study. The sub-chronic administration of rats with methanol extract did not bring about marked changes in the behavior body weight food and water intake urination and defecation pattern biochemical. parameters urea bilirubin creatinine alanine aminotransferase and aspartate aminotransferaseas well as histological profiles of rats when compared to the control. The methanol extract of F deltoidea was considered as at least non-toxic for consumption by the diabetic rats via the oral route.

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Item Type:	Proceedings Paper
Additional Information:	Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. mal QK99 M3S471 2008 Call Number
AGROVOC Term:	ACUTE TOXICITY
AGROVOC Term:	FICUS
AGROVOC Term:	DIABETES
AGROVOC Term:	METHANOL
AGROVOC Term:	EXTRACTS
AGROVOC Term:	MORACEAE
AGROVOC Term:	MALAYSIA
Geographical Term:	MALAYSIA
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 05:14
URI:	http://webagris.upm.edu.my/id/eprint/11381

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