Citation
Daud Ahmad I. A., . and Wan Mastura S M., . and Puziah H., . and Saripah R., . and Syamimi K., . and Aidawati M S., . and Mohd Roslan S., . (2009) Analgesic effect of aqueous extract of Garcinia nigrolineata Planch ex T. Anderson - a preliminary study. [Proceedings Paper]
Abstract
The analgesic effect of the Garcinia nigrolineata extract was assessed using the acetic acid-induced abdominal constriction model and formalin test. The extract 60-600 mg/kg caused a dose dependent inhibition on abdominal constriction induced by acetic acid 51.76 - 73.33. The extract also significantly P0.05 inhibited both phases of the formalin test suggesting the direct effect of the extract on the nocciceptor and to some extent an inhibition of endogenous inflammatory mediators. Moreover pre-treatment with naloxone an opioid receptor antagonist failed to modify the analgesic effect of the extract suggesting that the opioid system is not involved in this effect.
Download File
Full text available from:
|
Abstract
The analgesic effect of the Garcinia nigrolineata extract was assessed using the acetic acid-induced abdominal constriction model and formalin test. The extract 60-600 mg/kg caused a dose dependent inhibition on abdominal constriction induced by acetic acid 51.76 - 73.33. The extract also significantly P0.05 inhibited both phases of the formalin test suggesting the direct effect of the extract on the nocciceptor and to some extent an inhibition of endogenous inflammatory mediators. Moreover pre-treatment with naloxone an opioid receptor antagonist failed to modify the analgesic effect of the extract suggesting that the opioid system is not involved in this effect.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. mal QK99 M3S471 2008 Call Number |
| AGROVOC Term: | ANALGESICS |
| AGROVOC Term: | EXTRACTS |
| AGROVOC Term: | GARCINIA |
| AGROVOC Term: | ACETIC ACID |
| AGROVOC Term: | FORMALDEHYDE |
| AGROVOC Term: | MALAYSIA |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:14 |
| URI: | http://webagris.upm.edu.my/id/eprint/11389 |
Actions (login required)
 |
View Item |
