Citation
Nurhanan M. Y., . and Huq F., . and Beale P., . and Anee Suryani S., . (2010) In vitro studies on synergism in combinations of curcumin and platinum-based drugs against ovarian tumour models. [Proceedings Paper]
Abstract
Ovarian cancer remains an on-going challenge due to its detection at a late stage when the cancer is likely to have spread beyond the ovaries and when treated with the chemotherapy drugs the body sooner or later becoming resistance to it in which reduce the chance to survive. Among frequently used chemotherapy drugs are the platinums such as cisplatin and oxaliplatin. Combined chemotherapy is known to be more effective than monotherapy. Moreover many patients are taking phytochemicals in various forms i.e. food drink herbs and its products together with the chemotherapy drug. Such chemical may include Curcuma tonga L. or commonly known as turmeric. We initiated a study by combining curcumin a major compound in turmeric with platinum-based chemotheraphy drugs as to evaluate their cytotoxic effects compared to the drugs when treated alone in a series of ovarian cancer cell lines A2780 A2780ciSR and A2780ZD0473R using five different sequences of additions: 0/0 h 4/0 h 0/4 h 24/0 hand 0/24 h. The combination index CI based on Chou and Talalay;s median effect equation was used to assess the combined action between curcumin and the platinums. Cis 1 1 and 1 indicated synergism better than the drug treated alone additiveness same as the drug treated alone and antagonism worse than the drug treated alone respectively.
Download File
Full text available from:
|
Abstract
Ovarian cancer remains an on-going challenge due to its detection at a late stage when the cancer is likely to have spread beyond the ovaries and when treated with the chemotherapy drugs the body sooner or later becoming resistance to it in which reduce the chance to survive. Among frequently used chemotherapy drugs are the platinums such as cisplatin and oxaliplatin. Combined chemotherapy is known to be more effective than monotherapy. Moreover many patients are taking phytochemicals in various forms i.e. food drink herbs and its products together with the chemotherapy drug. Such chemical may include Curcuma tonga L. or commonly known as turmeric. We initiated a study by combining curcumin a major compound in turmeric with platinum-based chemotheraphy drugs as to evaluate their cytotoxic effects compared to the drugs when treated alone in a series of ovarian cancer cell lines A2780 A2780ciSR and A2780ZD0473R using five different sequences of additions: 0/0 h 4/0 h 0/4 h 24/0 hand 0/24 h. The combination index CI based on Chou and Talalay;s median effect equation was used to assess the combined action between curcumin and the platinums. Cis 1 1 and 1 indicated synergism better than the drug treated alone additiveness same as the drug treated alone and antagonism worse than the drug treated alone respectively.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | 2 tables; 22 ref. SB 293 S471 2010 |
| AGROVOC Term: | Synergism |
| AGROVOC Term: | Cytotoxicity |
| AGROVOC Term: | Curcumin |
| AGROVOC Term: | Platinum |
| AGROVOC Term: | Cancer disease |
| AGROVOC Term: | Chemotherapy |
| AGROVOC Term: | In vitro |
| AGROVOC Term: | Ovarian diseases |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:14 |
| URI: | http://webagris.upm.edu.my/id/eprint/11534 |
Actions (login required)
 |
View Item |
