In vitro studies on synergism in combinations of curcumin and platinum-based drugs against ovarian tumour models


Citation

Nurhanan M. Y., . and Huq F., . and Beale P., . and Anee Suryani S., . (2010) In vitro studies on synergism in combinations of curcumin and platinum-based drugs against ovarian tumour models. [Proceedings Paper]

Abstract

Ovarian cancer remains an on-going challenge due to its detection at a late stage when the cancer is likely to have spread beyond the ovaries and when treated with the chemotherapy drugs the body sooner or later becoming resistance to it in which reduce the chance to survive. Among frequently used chemotherapy drugs are the platinums such as cisplatin and oxaliplatin. Combined chemotherapy is known to be more effective than monotherapy. Moreover many patients are taking phytochemicals in various forms i.e. food drink herbs and its products together with the chemotherapy drug. Such chemical may include Curcuma tonga L. or commonly known as turmeric. We initiated a study by combining curcumin a major compound in turmeric with platinum-based chemotheraphy drugs as to evaluate their cytotoxic effects compared to the drugs when treated alone in a series of ovarian cancer cell lines A2780 A2780ciSR and A2780ZD0473R using five different sequences of additions: 0/0 h 4/0 h 0/4 h 24/0 hand 0/24 h. The combination index CI based on Chou and Talalay;s median effect equation was used to assess the combined action between curcumin and the platinums. Cis 1 1 and 1 indicated synergism better than the drug treated alone additiveness same as the drug treated alone and antagonism worse than the drug treated alone respectively.


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Abstract

Ovarian cancer remains an on-going challenge due to its detection at a late stage when the cancer is likely to have spread beyond the ovaries and when treated with the chemotherapy drugs the body sooner or later becoming resistance to it in which reduce the chance to survive. Among frequently used chemotherapy drugs are the platinums such as cisplatin and oxaliplatin. Combined chemotherapy is known to be more effective than monotherapy. Moreover many patients are taking phytochemicals in various forms i.e. food drink herbs and its products together with the chemotherapy drug. Such chemical may include Curcuma tonga L. or commonly known as turmeric. We initiated a study by combining curcumin a major compound in turmeric with platinum-based chemotheraphy drugs as to evaluate their cytotoxic effects compared to the drugs when treated alone in a series of ovarian cancer cell lines A2780 A2780ciSR and A2780ZD0473R using five different sequences of additions: 0/0 h 4/0 h 0/4 h 24/0 hand 0/24 h. The combination index CI based on Chou and Talalay;s median effect equation was used to assess the combined action between curcumin and the platinums. Cis 1 1 and 1 indicated synergism better than the drug treated alone additiveness same as the drug treated alone and antagonism worse than the drug treated alone respectively.

Additional Metadata

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Item Type: Proceedings Paper
Additional Information: 2 tables; 22 ref. SB 293 S471 2010
AGROVOC Term: Synergism
AGROVOC Term: Cytotoxicity
AGROVOC Term: Curcumin
AGROVOC Term: Platinum
AGROVOC Term: Cancer disease
AGROVOC Term: Chemotherapy
AGROVOC Term: In vitro
AGROVOC Term: Ovarian diseases
Geographical Term: MALAYSIA
Depositing User: Ms. Suzila Mohamad Kasim
Last Modified: 24 Apr 2025 05:14
URI: http://webagris.upm.edu.my/id/eprint/11534

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