Antifungal activity of some medicinal plants

Ahmad-Raus R., . and Jamal P., . and Abdullah E., . and Santhanam J., . (2010) Antifungal activity of some medicinal plants. [Proceedings Paper]

Natural products have long been providing important drugs for infectious disease including fungal infections that are known to be the main cause of death in immuno-compromised patients. Plants are known to produce a lot of secondary metabolites which are recognized as a useful source of new drugs. In this study the extraction of seven potential medicinal plants for antifungal compounds in four different solvents distilled water methanol ethyl acetate and hexane was carried out. The extraction process condition was set to 300 rpm agitation for 10 hours at room temperature. Agar disc diffusion method against Aspergillus niger Aspergillus fumigatus and Fusarium solani was adopted to determine the antifungal activity. The plants involved were Val/aris glabra Ktze. ;kesidang; Mussaenda philipica Aurorae ;bunga janda kaya kuning; Cherodendrum paniculatum L. ;pokok pagoda; Artocarpus elasticus Reinw. ex Blume ;pokok terap; Alpinia galangal L. Willd ;lengkuas; Senna alata L. ;gelenggang besar; and Curcuma longa L. ;kunyit;. Only methanol ethyl acetate and hexane extracts of A. galanga inhibited the growth of all tested organism. A. galanga methanolic extract MIC value 1.25 ug/ul has the highest antifungal activity compared to the other two types of extract. This study suggested that A. galanga;s could be considered as a potential plant to for further studies.

Full text available from:

Abstract

Natural products have long been providing important drugs for infectious disease including fungal infections that are known to be the main cause of death in immuno-compromised patients. Plants are known to produce a lot of secondary metabolites which are recognized as a useful source of new drugs. In this study the extraction of seven potential medicinal plants for antifungal compounds in four different solvents distilled water methanol ethyl acetate and hexane was carried out. The extraction process condition was set to 300 rpm agitation for 10 hours at room temperature. Agar disc diffusion method against Aspergillus niger Aspergillus fumigatus and Fusarium solani was adopted to determine the antifungal activity. The plants involved were Val/aris glabra Ktze. ;kesidang; Mussaenda philipica Aurorae ;bunga janda kaya kuning; Cherodendrum paniculatum L. ;pokok pagoda; Artocarpus elasticus Reinw. ex Blume ;pokok terap; Alpinia galangal L. Willd ;lengkuas; Senna alata L. ;gelenggang besar; and Curcuma longa L. ;kunyit;. Only methanol ethyl acetate and hexane extracts of A. galanga inhibited the growth of all tested organism. A. galanga methanolic extract MIC value 1.25 ug/ul has the highest antifungal activity compared to the other two types of extract. This study suggested that A. galanga;s could be considered as a potential plant to for further studies.

[error in script]

Item Type:	Proceedings Paper
Additional Information:	2 tables; 7 refs. SB 293 S471 2010
AGROVOC Term:	Antifungal agents
AGROVOC Term:	Aspergillus niger
AGROVOC Term:	Aspergillus fumigatus
AGROVOC Term:	Fusarium solani
AGROVOC Term:	Medicinal plants
Geographical Term:	MALAYSIA
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 05:14
URI:	http://webagris.upm.edu.my/id/eprint/11536

Actions (login required)

View Item