Therapeutic and pharmaceutical potentials of Asian Annonaceae

Kamarudin Mat-Salleh, . and Jackson Donna, . (2006) Therapeutic and pharmaceutical potentials of Asian Annonaceae. [Proceedings Paper]

Members of the pantropical Annonaceae are common understorey treelets shrubs and climbers in moist tropical lowland evergreen forests of Southeast Asia. Rarely utilised except some softwoods from Polyalthia Monocarpia Mezzettia and Platymitra they are widely used as medicinal plants amongst local natives. Among their uses perhaps the most acclaimed therapeutic value is its role as post-partum decoction or locally known in Malaysia as ubat meroyan or ubat periok. They are also believed to be effective as agents for abortion or contraception. They are also being utilised for treatment of varied disorders such as abscess amenorrhea asthma cough distention dyspepsia ecbolic fever intoxication rheumatism scabies or dermatitis toothache ulcer and wounds. Other therapeutic claims include their use as antispasmodic antivenin aphrodisiac insect repellant milk stimulant and purgative. Species of Annonaceae are also notable for having fragrant flowers and one of the important sources of local perfumaries. In Asian countries these species are widely cultivated for aestaetic or ornamental reasons and hold potential in fast expanding health-care products. Early 1980;s studies on some Annonaceae species showed that they contain unique constituents especially apophinoid alkaloids that might prove pharmacologically interesting and worthy of further investigations. Other non-alkaloids such as altholactones from styryl dehydropyrone group found in most species of Goniothalamus have also been proven to be an active abortifacient and tumor inhabitants. Many other species of Goniothalamus were screened and detail chemical analyses were carried out. Reports have shown that these pharmaceutical agents are profound antifertility properties attributed by its progesteron and estrogen antagonistic activities. These hormones are associated with breast cancer development and the potential use lies with these activities which may later marketed as potent antitumors with an alternative to popular breast cancer hormonal antagonists such as RU486 and tamoxifen.

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Abstract

Members of the pantropical Annonaceae are common understorey treelets shrubs and climbers in moist tropical lowland evergreen forests of Southeast Asia. Rarely utilised except some softwoods from Polyalthia Monocarpia Mezzettia and Platymitra they are widely used as medicinal plants amongst local natives. Among their uses perhaps the most acclaimed therapeutic value is its role as post-partum decoction or locally known in Malaysia as ubat meroyan or ubat periok. They are also believed to be effective as agents for abortion or contraception. They are also being utilised for treatment of varied disorders such as abscess amenorrhea asthma cough distention dyspepsia ecbolic fever intoxication rheumatism scabies or dermatitis toothache ulcer and wounds. Other therapeutic claims include their use as antispasmodic antivenin aphrodisiac insect repellant milk stimulant and purgative. Species of Annonaceae are also notable for having fragrant flowers and one of the important sources of local perfumaries. In Asian countries these species are widely cultivated for aestaetic or ornamental reasons and hold potential in fast expanding health-care products. Early 1980;s studies on some Annonaceae species showed that they contain unique constituents especially apophinoid alkaloids that might prove pharmacologically interesting and worthy of further investigations. Other non-alkaloids such as altholactones from styryl dehydropyrone group found in most species of Goniothalamus have also been proven to be an active abortifacient and tumor inhabitants. Many other species of Goniothalamus were screened and detail chemical analyses were carried out. Reports have shown that these pharmaceutical agents are profound antifertility properties attributed by its progesteron and estrogen antagonistic activities. These hormones are associated with breast cancer development and the potential use lies with these activities which may later marketed as potent antitumors with an alternative to popular breast cancer hormonal antagonists such as RU486 and tamoxifen.

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Item Type:	Proceedings Paper
Additional Information:	Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. RS180 M3I61 2005 Call Number
AGROVOC Term:	Pharmaceutical plants
AGROVOC Term:	Annonaceae
AGROVOC Term:	Lowland
AGROVOC Term:	Medicinal plants
AGROVOC Term:	Traditional medicines
AGROVOC Term:	Tropical rain forests
Geographical Term:	MALAYSIA
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 05:14
URI:	http://webagris.upm.edu.my/id/eprint/11707

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