Phytate did not affect fecal endogenous excretion of zinc but suppressed its true absorption in rats

Ohmori H., . and Okumura H., . and Matsui T., . and Yano H., . (2004) Phytate did not affect fecal endogenous excretion of zinc but suppressed its true absorption in rats. [Proceedings Paper]

We detennined the effect of dietary phytate on true absorption and fecal endogenous excretion ofzinc in rats using a stable isotope ofzinc 67Zn. Rats were given diets mainly consisting of casein and starch. Sodium phytate was added at 1.2 into the diet. Rats were surgically implanted an osmotic pump to infuse 67Zn for 1 week at a rate of 24 Ilg/day. Feces and urine were collected during infusion to detennine total zinc by atomic absorption spectrometer and 67Zn enrichment by an inductively coupled plasma mass spectrometer ICP-MS. Since fecal and urinary enrichments of 67Zn became stable 4 days after the initiation of infusion fecal endogenous excretion and true absorption of zinc were calculated from total zinc and 67Zn enrichment in fecal and urinary samples collected between 5 and 7 day of infusion. Dietary phytate did not affect fecal endogenous zinc but suppressed true absorption of zinc. These results indicated that dietary phytate decreased the apparent absorption of zinc through suppressing its true absorption.

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Abstract

We detennined the effect of dietary phytate on true absorption and fecal endogenous excretion ofzinc in rats using a stable isotope ofzinc 67Zn. Rats were given diets mainly consisting of casein and starch. Sodium phytate was added at 1.2 into the diet. Rats were surgically implanted an osmotic pump to infuse 67Zn for 1 week at a rate of 24 Ilg/day. Feces and urine were collected during infusion to detennine total zinc by atomic absorption spectrometer and 67Zn enrichment by an inductively coupled plasma mass spectrometer ICP-MS. Since fecal and urinary enrichments of 67Zn became stable 4 days after the initiation of infusion fecal endogenous excretion and true absorption of zinc were calculated from total zinc and 67Zn enrichment in fecal and urinary samples collected between 5 and 7 day of infusion. Dietary phytate did not affect fecal endogenous zinc but suppressed true absorption of zinc. These results indicated that dietary phytate decreased the apparent absorption of zinc through suppressing its true absorption.

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Item Type:	Proceedings Paper
Additional Information:	Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia HD9410.1 A111 2004 vol.3 Call Number
AGROVOC Term:	Phytates
AGROVOC Term:	Zinc
AGROVOC Term:	Excretion
AGROVOC Term:	Absorption
AGROVOC Term:	Urinary tract
Geographical Term:	MALAYSIA
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 05:14
URI:	http://webagris.upm.edu.my/id/eprint/12051

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