Variable effects of different dietary saturated fatty acids on human postprandial lipaemia

Tilakavati Karupaiah, . and Sundram K., . and Fatmawati O., . and Ismail M.N., . (2005) Variable effects of different dietary saturated fatty acids on human postprandial lipaemia. [Proceedings Paper]

Increased postprandial lipaemia enhances atherogenic potentials in humans. The effects of variance in dietary saturated fatty acid (SFA) composition on postprandial lipaemia was examined in 20 normolipaemic volunteers who were sequentially challenged with 3 diets with different SFA content (12:0+14:0, P/S 0.19; 16:0, P/S 0.31; 18:0, P/S 0.22). All diets provided total fat at 31% energy with test fat contributing 85%. Subjects were preconditioned on the diets for 7 days prior to the postprandial challenge with 50g of test fat in a single breakfast meal. Blood was sampled at baseline (fasted) and 5 times postprandially (2h, 4h, 5h, 6h, 8h). Plasma cholesterol (TC), triacylglycerol (TAG), and lipoproteins were isolated by ultracentrifugation Postprandial response was influenced by the nature of dietary saturates tested. The 18:0 diet mediated the highest TAG response, which was significantly higher than the 16:0 and 12:0+14:0 diets. Pp peaks for TAG occurred at 5h for the 18:0 diet, 4h for the 16:0 diet and 2h for 12:0+14:0 diet. In tandem with the TAG responses, VLDL-C for the 18:0 diet peaked at 6h compared to the 4h peaks for 12:0+14:0 and 16:0 diets. After 2h HDL-C was significantly increased by the 12:0+14:0 and 16:0 diets compared to the 18:0 diet. Thereafter, HDL-C remained depressed by the 18:0 diet for the rest of the Pp periods. TC response was significantly raised by the 12:0+14:0 diet compared to 16:0 and 18:0 diets for the whole postprandial period. This study demonstrates that postprandial lipaemia and lipoproteins are affected by the type of SFA in the diet. The nature of dietary saturates influences fat digestion and absorption in humans, in turn affecting blood lipids and lipoproteins and their role in modulating cardiovascular risk factors.

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Abstract

Increased postprandial lipaemia enhances atherogenic potentials in humans. The effects of variance in dietary saturated fatty acid (SFA) composition on postprandial lipaemia was examined in 20 normolipaemic volunteers who were sequentially challenged with 3 diets with different SFA content (12:0+14:0, P/S 0.19; 16:0, P/S 0.31; 18:0, P/S 0.22). All diets provided total fat at 31% energy with test fat contributing 85%. Subjects were preconditioned on the diets for 7 days prior to the postprandial challenge with 50g of test fat in a single breakfast meal. Blood was sampled at baseline (fasted) and 5 times postprandially (2h, 4h, 5h, 6h, 8h). Plasma cholesterol (TC), triacylglycerol (TAG), and lipoproteins were isolated by ultracentrifugation Postprandial response was influenced by the nature of dietary saturates tested. The 18:0 diet mediated the highest TAG response, which was significantly higher than the 16:0 and 12:0+14:0 diets. Pp peaks for TAG occurred at 5h for the 18:0 diet, 4h for the 16:0 diet and 2h for 12:0+14:0 diet. In tandem with the TAG responses, VLDL-C for the 18:0 diet peaked at 6h compared to the 4h peaks for 12:0+14:0 and 16:0 diets. After 2h HDL-C was significantly increased by the 12:0+14:0 and 16:0 diets compared to the 18:0 diet. Thereafter, HDL-C remained depressed by the 18:0 diet for the rest of the Pp periods. TC response was significantly raised by the 12:0+14:0 diet compared to 16:0 and 18:0 diets for the whole postprandial period. This study demonstrates that postprandial lipaemia and lipoproteins are affected by the type of SFA in the diet. The nature of dietary saturates influences fat digestion and absorption in humans, in turn affecting blood lipids and lipoproteins and their role in modulating cardiovascular risk factors.

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Item Type:	Proceedings Paper
Additional Information:	Available at Perpustakaan Sultan Abdul Samad, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. TP684 P3I61 2005 Call Number
AGROVOC Term:	fatty acids
AGROVOC Term:	blood lipids
AGROVOC Term:	lipid metabolism
AGROVOC Term:	human nutrition
AGROVOC Term:	nutritive value
AGROVOC Term:	sampling
AGROVOC Term:	statistical methods
AGROVOC Term:	scientists
AGROVOC Term:	human health
Geographical Term:	Malaysia
Depositing User:	Nor Hasnita Abdul Samat
Date Deposited:	01 Nov 2025 06:17
Last Modified:	01 Nov 2025 06:17
URI:	http://webagris.upm.edu.my/id/eprint/1211

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