Cardioprotective abilities of palm oil derived tocotrienol rich factor

Das Samarjit, . and Kalanithi Nesaretnam, . and Dipak K. Das, . (2005) Cardioprotective abilities of palm oil derived tocotrienol rich factor. [Proceedings Paper]

Several studies exist in the literature demonstrating cardioprotective ability of tocotrienol-rich factor (TRF) derived from palm oil. Numerous reports exist to show various health benefits of tocotrienols, isomers of vitamin E. In acute experiments, pre-perfusion of the isolated rat hearts with TRF was associated with improved post-ischemic ventricular function, reduced myocardial infarct size and decreased number of apoptotic cardiomyocytes, and reduced electrical rhythm disturbances compared to control. The diet supplemented with TRF for 7 days also exhibited improved ventricular recovery and reduced myocardial infarct size, the recovery was further enhanced after 15 days of TRF consumption. Interestingly, TRF inhibited the phosphorylation of c-Src and stabilized proteasome. It appears that inhibition of ischemia/reperfusion-mediated c-Src activation and proteasome stabilization play a crucial role for the cardioprotective ability of TRF.

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Abstract

Several studies exist in the literature demonstrating cardioprotective ability of tocotrienol-rich factor (TRF) derived from palm oil. Numerous reports exist to show various health benefits of tocotrienols, isomers of vitamin E. In acute experiments, pre-perfusion of the isolated rat hearts with TRF was associated with improved post-ischemic ventricular function, reduced myocardial infarct size and decreased number of apoptotic cardiomyocytes, and reduced electrical rhythm disturbances compared to control. The diet supplemented with TRF for 7 days also exhibited improved ventricular recovery and reduced myocardial infarct size, the recovery was further enhanced after 15 days of TRF consumption. Interestingly, TRF inhibited the phosphorylation of c-Src and stabilized proteasome. It appears that inhibition of ischemia/reperfusion-mediated c-Src activation and proteasome stabilization play a crucial role for the cardioprotective ability of TRF.

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Item Type:	Proceedings Paper
Additional Information:	Available at Perpustakaan Sultan Abdul Samad, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. TP684 P3I61 2005 Call Number
AGROVOC Term:	palm oils
AGROVOC Term:	cardiovascular diseases
AGROVOC Term:	extraction
AGROVOC Term:	food supplements
AGROVOC Term:	experimentation
AGROVOC Term:	tocotrienols
AGROVOC Term:	antioxidants
AGROVOC Term:	human health
Geographical Term:	Malaysia
Depositing User:	Nor Hasnita Abdul Samat
Date Deposited:	01 Nov 2025 07:43
Last Modified:	03 Feb 2026 03:59
URI:	http://webagris.upm.edu.my/id/eprint/1218

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