Citation
K. Khalid, . and Yap A. L. C., . and M. A. Sukari, . and Ee G. C. L., . and M. Rahmani, . (2008) Cytotoxic constituents from Boesenbergia rotunda L. Mansf. Kulturpfl. [Proceedings Paper]
Abstract
Three flavanones pinostrobin l pinocembrin 2 and alpinetin 3 together with two chalcones cardamonin 4 and boesenbergin A 5 were isolated from the hexane and chloroform extracts of rhizomes of Boesenbergia rotunda L. Mansf. Kulturpfl. The structures of all compounds were elucidated on the basis of spectroscopic methods IR MS and NMR. As a complementary to the spectroscopic data reported previously the 2-D NMR was carried out to elucidate the structure of boesenbergin A. The extracts and pure compounds were screened for cytotoxic activity against HL-60 human promyelocytic leukemia cancer cell lines. Cytotoxic screening showed most of the extracts and pure compounds of Boesenbergia rotunda were active against HL-60 cancer cell line. The chloroform extract and boesenbergin A showed the most potent cytotoxic activity with lC50 value of 5.8 g/ml
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Abstract
Three flavanones pinostrobin l pinocembrin 2 and alpinetin 3 together with two chalcones cardamonin 4 and boesenbergin A 5 were isolated from the hexane and chloroform extracts of rhizomes of Boesenbergia rotunda L. Mansf. Kulturpfl. The structures of all compounds were elucidated on the basis of spectroscopic methods IR MS and NMR. As a complementary to the spectroscopic data reported previously the 2-D NMR was carried out to elucidate the structure of boesenbergin A. The extracts and pure compounds were screened for cytotoxic activity against HL-60 human promyelocytic leukemia cancer cell lines. Cytotoxic screening showed most of the extracts and pure compounds of Boesenbergia rotunda were active against HL-60 cancer cell line. The chloroform extract and boesenbergin A showed the most potent cytotoxic activity with lC50 value of 5.8 g/ml
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Available at Perpustakaan Sultan Abdul Samad Uni-versiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. mal RM666 H33 B573 Call Number |
| AGROVOC Term: | Zingiberaceae |
| AGROVOC Term: | Herbaceous plants |
| AGROVOC Term: | Plant extracts |
| AGROVOC Term: | Chemical composition |
| AGROVOC Term: | Isolation |
| AGROVOC Term: | Extraction |
| AGROVOC Term: | Separation |
| AGROVOC Term: | Melting point |
| AGROVOC Term: | Nuclear magnetic resonance spectroscopy |
| AGROVOC Term: | Column chromatography |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:15 |
| URI: | http://webagris.upm.edu.my/id/eprint/12862 |
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