Citation
Taylor Walter C., . (2008) Recent studies on himbacine a Galbulimima alkaloid. [Proceedings Paper]
Abstract
Himbacine one of many unique alkaloids isolated from the Australian rainforest tree Galbulimima belgraveana has attracted attention as a lead compound for drug development because of it being a significant muscarinic antagonist with selectivity for M‚‚ receptor sites. Efforts to prepare analogues based on the himbacine structure effective for the treatment of Alzheimer;s disease have so far been unsuccessful but other studies have had success. Also compounds based on the enantiomeric structure of himbacine have shown potent activity as PAR-1 antagonists and may be of use in the treatment of cardiovascular diseases.
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Abstract
Himbacine one of many unique alkaloids isolated from the Australian rainforest tree Galbulimima belgraveana has attracted attention as a lead compound for drug development because of it being a significant muscarinic antagonist with selectivity for M‚‚ receptor sites. Efforts to prepare analogues based on the himbacine structure effective for the treatment of Alzheimer;s disease have so far been unsuccessful but other studies have had success. Also compounds based on the enantiomeric structure of himbacine have shown potent activity as PAR-1 antagonists and may be of use in the treatment of cardiovascular diseases.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Available at Perpustakaan Sultan Abdul Samad Uni-versiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. mal RM666 H33 B573 Call Number |
| AGROVOC Term: | Magnoliales |
| AGROVOC Term: | Forest trees |
| AGROVOC Term: | Rain forests |
| AGROVOC Term: | Alkaloids |
| AGROVOC Term: | Bark |
| AGROVOC Term: | Chemical composition |
| AGROVOC Term: | Chemical structure |
| AGROVOC Term: | Medicinal properties |
| AGROVOC Term: | Pharmacology |
| AGROVOC Term: | Human diseases |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:15 |
| URI: | http://webagris.upm.edu.my/id/eprint/12870 |
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