Citation
Chowdhry Md. Rabiul Hasan, . and Md. Jamirul Islam, . and Md. Salim Uddin, . and Md. Rezaul Karim, . (2011) Antimicrobial and cytotoxic activity of raintree Samanea saman pod pulp. [Proceedings Paper]
Abstract
The life threatening infections caused by pathogenic microorganisms increased worldwide. Although huge numbers of antibiotics have been discovered they gradually get resistant to the microbes. Irrational use of antibiotics is a major cause of such resistance. So it is undoubtedly very important to discover new effective antibiotics. This article reports for the first time the antibacterial and cytotoxic effect of raintree pod pulp extracts at green and ripen stages. This study demonstrated that 100-200 g/disc of each fraction exhibited appreciable activity against all the tested 12 strains of bacteria. Ethyl acetate fraction showed highest activity against Shigella dysenteriae and Chloroform fraction against Salmonella typhi. The MIC of each crude fraction was determined against 8 strains of bacteria. The Ethyl acetate fraction of green pulp extract and chloroform fraction of ripen pulp extract gave the lowest MIC values against most of the tested organisms. Water fraction from green pulp and ethyl acetate fraction from ripen pulp showed highst cytotoxicity against brine shrimp. Petroleum ether fraction from both green and ripen pulp exhibited almost similar mortality rate. The chemical nature of the different fractions was determined by TLC to be steroid glycoside heterocyclic terpene and flavonoids.
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Abstract
The life threatening infections caused by pathogenic microorganisms increased worldwide. Although huge numbers of antibiotics have been discovered they gradually get resistant to the microbes. Irrational use of antibiotics is a major cause of such resistance. So it is undoubtedly very important to discover new effective antibiotics. This article reports for the first time the antibacterial and cytotoxic effect of raintree pod pulp extracts at green and ripen stages. This study demonstrated that 100-200 g/disc of each fraction exhibited appreciable activity against all the tested 12 strains of bacteria. Ethyl acetate fraction showed highest activity against Shigella dysenteriae and Chloroform fraction against Salmonella typhi. The MIC of each crude fraction was determined against 8 strains of bacteria. The Ethyl acetate fraction of green pulp extract and chloroform fraction of ripen pulp extract gave the lowest MIC values against most of the tested organisms. Water fraction from green pulp and ethyl acetate fraction from ripen pulp showed highst cytotoxicity against brine shrimp. Petroleum ether fraction from both green and ripen pulp exhibited almost similar mortality rate. The chemical nature of the different fractions was determined by TLC to be steroid glycoside heterocyclic terpene and flavonoids.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. QR22 M3I61 2011 vol.2 Call Number. |
| AGROVOC Term: | Samanea saman |
| AGROVOC Term: | Fabaceae |
| AGROVOC Term: | Raintree |
| AGROVOC Term: | Pulp |
| AGROVOC Term: | Extracts |
| AGROVOC Term: | Antibacterial properties |
| AGROVOC Term: | Cytotoxicity |
| AGROVOC Term: | Bacteria |
| AGROVOC Term: | Gram negative bacteria |
| AGROVOC Term: | Gram positive bacteria |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:15 |
| URI: | http://webagris.upm.edu.my/id/eprint/12953 |
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