Citation
Zainuddin lIIias, . and Wan Norhana Noordin, . and Fatimah Abu Bakar, . and Blunt John, . and Nor Ainy Mahyudin, . and Cole Anthony, . and Nazamid Saari, . and Munro Murray, . (2011) Screening Malaysian marine fungal extracts for cytotoxic activity. [Proceedings Paper]
Abstract
Fungi were successfully isolated from Malaysian marine invertebrates. A total of 57 fungal extracts were screened against P388 cells. The quick screening assay showed that 25 of 57 of the extracts 43.9 inhibited 50 of the P388 cells. Of the 25 active extracts 10 40 showed IC‚‚12 500 ng/mL. The strongest cytotoxic activity was shown by extract F6451 with IC‚‚3 886 ng/mL. Four known metabolites namely; meleagrine cytochalasins 3-indolyl carboxylic acid and dehydrosterigmatocystin were dereplicated by the HPLC screening. The screening provided a basis for selection of extracts for further investigation.
Download File
Full text available from:
|
Abstract
Fungi were successfully isolated from Malaysian marine invertebrates. A total of 57 fungal extracts were screened against P388 cells. The quick screening assay showed that 25 of 57 of the extracts 43.9 inhibited 50 of the P388 cells. Of the 25 active extracts 10 40 showed IC‚‚12 500 ng/mL. The strongest cytotoxic activity was shown by extract F6451 with IC‚‚3 886 ng/mL. Four known metabolites namely; meleagrine cytochalasins 3-indolyl carboxylic acid and dehydrosterigmatocystin were dereplicated by the HPLC screening. The screening provided a basis for selection of extracts for further investigation.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. QR22 M3I61 2011 vol.2 Call Number. |
| AGROVOC Term: | Fungi |
| AGROVOC Term: | Marine animals |
| AGROVOC Term: | Cells |
| AGROVOC Term: | Microorganisms |
| AGROVOC Term: | Extracts |
| AGROVOC Term: | Screening tests |
| AGROVOC Term: | Isolation of microorganisms |
| AGROVOC Term: | HPLC |
| AGROVOC Term: | Cytotoxicity |
| AGROVOC Term: | Metabolites |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:15 |
| URI: | http://webagris.upm.edu.my/id/eprint/13105 |
Actions (login required)
 |
View Item |
