Silvestrol : An emerging compound for cancer therapy

Yeo T. C., . (2010) Silvestrol : An emerging compound for cancer therapy. [Proceedings Paper]

Silverstrol is a rocaglate derivative that was isolated from the bark fruits and twigs of Aglaia sp. commonly found in Malaysia and Indonesia. This compound showed potent in-vitro cytotoxic activity against several human cancer cell lines including lung prostrate and breast cancer. Its activity is comparable to the well known cancer drug Paclitaxel Taxol Silvestrol is composed of a cyclopentabenzofuran core which is phytochemically confined to the genus Aglaia. It is attached to an unusual dioxyanyloxy group critical for its potent cytotoxic activity. The compound was active in P388 murine leukemia model and induced cell death through an apoptotic response in hormone-dependent human prostrate cancer cell line. Total synthesis of silvestrol and its enantiomer epi-silvestrol has been achieved by two different chemistry research groups. Recently silvestrol was reported to be selective in inhibiting B cells compared to T cells in chronic lymphocytic leukemia CLL patients; blood. This compound is currently being developed for Cll therapy by National Cancer Institute and Ohio State University Medical Centre USA. This paper provides a review of the related work as well as rsearch initiated by the Sarawak Biodiversity Centre and its collaborators to develop the patent of the compound owned by the Government of Sarawak.

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Abstract

Silverstrol is a rocaglate derivative that was isolated from the bark fruits and twigs of Aglaia sp. commonly found in Malaysia and Indonesia. This compound showed potent in-vitro cytotoxic activity against several human cancer cell lines including lung prostrate and breast cancer. Its activity is comparable to the well known cancer drug Paclitaxel Taxol Silvestrol is composed of a cyclopentabenzofuran core which is phytochemically confined to the genus Aglaia. It is attached to an unusual dioxyanyloxy group critical for its potent cytotoxic activity. The compound was active in P388 murine leukemia model and induced cell death through an apoptotic response in hormone-dependent human prostrate cancer cell line. Total synthesis of silvestrol and its enantiomer epi-silvestrol has been achieved by two different chemistry research groups. Recently silvestrol was reported to be selective in inhibiting B cells compared to T cells in chronic lymphocytic leukemia CLL patients; blood. This compound is currently being developed for Cll therapy by National Cancer Institute and Ohio State University Medical Centre USA. This paper provides a review of the related work as well as rsearch initiated by the Sarawak Biodiversity Centre and its collaborators to develop the patent of the compound owned by the Government of Sarawak.

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Item Type:	Proceedings Paper
Additional Information:	Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. TP248.14 I61 2008 Call Number.
AGROVOC Term:	Aglaia
AGROVOC Term:	Medicinal plants
AGROVOC Term:	Research and development
AGROVOC Term:	Phytochemistry
AGROVOC Term:	Isolation in chemical analysis
AGROVOC Term:	Bark
AGROVOC Term:	Fruits
AGROVOC Term:	Twigs
AGROVOC Term:	Chemical compounds
AGROVOC Term:	Medicinal properties
Geographical Term:	MALAYSIA
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 05:15
URI:	http://webagris.upm.edu.my/id/eprint/13147

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