Citation
Sutha D., . and Jegathambigai R., . and Sudhakaran S., . (2010) A study on the hepatoprotective effect of Andrographis paniculata on mice. [Proceedings Paper]
Abstract
Andrographis paniculata is a well known medicinal plant of Ayurveda with various pharmacological as well as medicinal properties. The present study determined the hepatoprotective effect of crude methanolic extracts of A. paniculata on mice. The phytochemical screening of the crude methanolic extracts of A. paniculata plant was also determined followed by the confirmation of the active compound using Thin Layer Chromatography. The hepatoprotective activity of methanolic extracts of A. panicufata was evaluated against paracetamol induced 500mg/kg hepatic damage in mice. The extracts at doses of 10mg/kg and 1OOmg/kg were orally administered at 24 and 72 hours time interval n each group. Histological analysis of the liver and the liver protein content was determined. The results of the study indicated that the crude extracts of A. paniculata at both doses exhibited a significant protective effect in the liver morphology of the paracetamol induced hepatotoxicity in mice. There was also a significant decrease P0.05 the liver protein content of the hepatotoxic mice after the treatments. The crude methanolic extracts of A. paniculata indicated the presence of phytochemical constituents such as flavonoid alkaloid tannin and terpenoids. Finally Thin Layer Chromatography confirmed the presence of active compound diterpene lactone or andrographolide which has contributed to the hepatoprotective activity of A paniculata Hence it can be concluded that treatment of low and high doses of A paniculata with time period revealed the hepatoprotective effect in mice.
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Abstract
Andrographis paniculata is a well known medicinal plant of Ayurveda with various pharmacological as well as medicinal properties. The present study determined the hepatoprotective effect of crude methanolic extracts of A. paniculata on mice. The phytochemical screening of the crude methanolic extracts of A. paniculata plant was also determined followed by the confirmation of the active compound using Thin Layer Chromatography. The hepatoprotective activity of methanolic extracts of A. panicufata was evaluated against paracetamol induced 500mg/kg hepatic damage in mice. The extracts at doses of 10mg/kg and 1OOmg/kg were orally administered at 24 and 72 hours time interval n each group. Histological analysis of the liver and the liver protein content was determined. The results of the study indicated that the crude extracts of A. paniculata at both doses exhibited a significant protective effect in the liver morphology of the paracetamol induced hepatotoxicity in mice. There was also a significant decrease P0.05 the liver protein content of the hepatotoxic mice after the treatments. The crude methanolic extracts of A. paniculata indicated the presence of phytochemical constituents such as flavonoid alkaloid tannin and terpenoids. Finally Thin Layer Chromatography confirmed the presence of active compound diterpene lactone or andrographolide which has contributed to the hepatoprotective activity of A paniculata Hence it can be concluded that treatment of low and high doses of A paniculata with time period revealed the hepatoprotective effect in mice.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. TP248.14 I61 2008 Call Number. |
| AGROVOC Term: | Acanthaceae |
| AGROVOC Term: | Medicinal plants |
| AGROVOC Term: | Herbaceous plants |
| AGROVOC Term: | Leaves |
| AGROVOC Term: | Methanol |
| AGROVOC Term: | Phytochemistry |
| AGROVOC Term: | Laboratory experimentation |
| AGROVOC Term: | Thin layer chromatography |
| AGROVOC Term: | Mice |
| AGROVOC Term: | Liver |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:15 |
| URI: | http://webagris.upm.edu.my/id/eprint/13149 |
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