Anti-hypercholesterolemic property of Phaleria macrocarpa fruit aqueous extract in hypercholesterolemia-induced rats

Chong S. C., . and Dollah M. A., . (2010) Anti-hypercholesterolemic property of Phaleria macrocarpa fruit aqueous extract in hypercholesterolemia-induced rats. [Proceedings Paper]

Phaleria macocarpa is a herb that been used in traditional medicine and has been claim that P. macocarpa could cure hypercholesterolemia diabetes cancer and others. The scientific on the therapeutic effects of this herb however is rather limited. In this study anti-hypercholesterolemic property of various concentration of Pm aqueous fruit extract and the extend of its effects compared with Simvastatin was determined In the study 36 female rats were divided into 6 groups equally. Five groups were fed with 3 pure cholesterol during pre treatment 2 weeks and treatment periods 4 weeks. Supplementation of 1 ml of the P. macocarpa extract 0 67 134 and 183 mg/kg bw and Simvastatin 0.33 mg/kg bw was given during treatment period. Blood samples were collected before and after the supplementation periods via cardiac puncture to analyse the total cholesterol TG triglycerides TRG high density lipid HDL and low density lipid LDL levels. The results shows that the mean difference of the total cholesterol after and before supplementation of P. macocarpa for negative control 0 67 134 183 mg/kg bw and simvastatin was 0.050.49 0.871.56 -0.951.74 -0.661.66 -0.590.48 and -0.480.61 mmollL. The mean difference for Triglycerides was -0.730.67 0.281.74 -3.141.68 -1241.16 -1.220.94 and 0.160.18 The mean difference for the HDL was 0.280.35 0.130.50 0.410.44 0.110.45 0.060.19 and -0.421 35 while the mean difference of the LDL was 0.070.08 0.350.53 0.221.28 -0.151.15 -0.480.75 and 0.050.54. The study concludes that P. macocarpa significantly reduced triglycerides level P0.05 and showed a tendency to reduce other lipid profiles. The effect of P. macocarpa supplementation was dose-dependant and P macocarpa at the concentration of 44 mg/kg bw showed the same cholesterol reducing effect as simvastatin. Thus P. macocarpa has anti hypercholesterolemic effect on hypercholesterolemic-induced rats

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Abstract

Phaleria macocarpa is a herb that been used in traditional medicine and has been claim that P. macocarpa could cure hypercholesterolemia diabetes cancer and others. The scientific on the therapeutic effects of this herb however is rather limited. In this study anti-hypercholesterolemic property of various concentration of Pm aqueous fruit extract and the extend of its effects compared with Simvastatin was determined In the study 36 female rats were divided into 6 groups equally. Five groups were fed with 3 pure cholesterol during pre treatment 2 weeks and treatment periods 4 weeks. Supplementation of 1 ml of the P. macocarpa extract 0 67 134 and 183 mg/kg bw and Simvastatin 0.33 mg/kg bw was given during treatment period. Blood samples were collected before and after the supplementation periods via cardiac puncture to analyse the total cholesterol TG triglycerides TRG high density lipid HDL and low density lipid LDL levels. The results shows that the mean difference of the total cholesterol after and before supplementation of P. macocarpa for negative control 0 67 134 183 mg/kg bw and simvastatin was 0.050.49 0.871.56 -0.951.74 -0.661.66 -0.590.48 and -0.480.61 mmollL. The mean difference for Triglycerides was -0.730.67 0.281.74 -3.141.68 -1241.16 -1.220.94 and 0.160.18 The mean difference for the HDL was 0.280.35 0.130.50 0.410.44 0.110.45 0.060.19 and -0.421 35 while the mean difference of the LDL was 0.070.08 0.350.53 0.221.28 -0.151.15 -0.480.75 and 0.050.54. The study concludes that P. macocarpa significantly reduced triglycerides level P0.05 and showed a tendency to reduce other lipid profiles. The effect of P. macocarpa supplementation was dose-dependant and P macocarpa at the concentration of 44 mg/kg bw showed the same cholesterol reducing effect as simvastatin. Thus P. macocarpa has anti hypercholesterolemic effect on hypercholesterolemic-induced rats

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Item Type:	Proceedings Paper
Additional Information:	Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. TP248.14 I61 2008 Call Number.
AGROVOC Term:	Thymelaeaceae
AGROVOC Term:	Traditional medicines
AGROVOC Term:	Disease treatment
AGROVOC Term:	Cholesterol
AGROVOC Term:	Laboratory experimentation
AGROVOC Term:	Fruit extracts
AGROVOC Term:	Blood sampling
AGROVOC Term:	Rats
AGROVOC Term:	Hypercholesterolaemia
AGROVOC Term:	Triglycerides
Geographical Term:	MALAYSIA
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 05:15
URI:	http://webagris.upm.edu.my/id/eprint/13154

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