Isolation and Characterization of Angiotensin Converting Enzyme ACE Inhibitory Compound derived from Tacca integrifolia

Farah L., . and Jamaludin M., . (2010) Isolation and Characterization of Angiotensin Converting Enzyme ACE Inhibitory Compound derived from Tacca integrifolia. [Proceedings Paper]

Tacca integrifolia from the family of Taccaceae locally known as belimbing tanah has been used traditionally to treat high blood pressure related disease. However no scientific research has been carried out to evaluate its effectiveness for antihypertension treatments. The bioactive compounds from the leaves and rhizomes of T. integrifolia were extracted with hexane petroleum ether methanol chloroform and water. The present of phenols terpenoids and alkaloids were detected with phenol vanillin and dragendorrfs reagents respectively. The crude extract of leaves and rhizomes shows more than 50 ACE inhibition. These findings provide evidence that the crude extract contains antihypertensive active compounds. Further research is still in progress to evaluate for its antihypertensive action by oral administration in spontaneously hypertensive rats SHR.

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Abstract

Tacca integrifolia from the family of Taccaceae locally known as belimbing tanah has been used traditionally to treat high blood pressure related disease. However no scientific research has been carried out to evaluate its effectiveness for antihypertension treatments. The bioactive compounds from the leaves and rhizomes of T. integrifolia were extracted with hexane petroleum ether methanol chloroform and water. The present of phenols terpenoids and alkaloids were detected with phenol vanillin and dragendorrfs reagents respectively. The crude extract of leaves and rhizomes shows more than 50 ACE inhibition. These findings provide evidence that the crude extract contains antihypertensive active compounds. Further research is still in progress to evaluate for its antihypertensive action by oral administration in spontaneously hypertensive rats SHR.

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Item Type:	Proceedings Paper
Additional Information:	Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. TP248.14 I61 2008 Call Number.
AGROVOC Term:	Tacca
AGROVOC Term:	Taccaceae
AGROVOC Term:	Extraction
AGROVOC Term:	Rhizomes
AGROVOC Term:	Isolation in chemical analysis
AGROVOC Term:	Identification
AGROVOC Term:	Extracts
AGROVOC Term:	Leaves
AGROVOC Term:	Phenols
AGROVOC Term:	Terpenoids
Geographical Term:	MALAYSIA
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 05:15
URI:	http://webagris.upm.edu.my/id/eprint/13164

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