Citation
Abdurahman H. N., . and Azhari H. N., . and Jessinta S., . and Mashitah M. Y., . (2013) Antibacterial activity of different extracts of Swietenia macrophylla king. [Proceedings Paper]
Abstract
The study was carried out to screen antimicrobial activity for a new natural nontoxic and effective antibiotic from plant extract. In this study Swietenia macrophylla King was selected and antibacterial activity of extracts from different parts leaf fruit cover seed cover with various solvents or different fractions of the extracts was evaluated. The antibacterial activity of these extracts was assessed against two multiple-drug-resistance bacteria strains namely Escherichia coli and Staphylococcus aureus using well diffusion method. For the antibacterial bioassay four concentrations 10 50 100 and 150 2 g/mL-‚� of each extract solutions were prepared. The antibacterial activity among extracts was extremely broad against both test organisms. Minimum inhibition concentration was done via serial dilution method. The MIC values of the extracts ranged from 8.1 to 21.2 g/mL-‚�. Among fractionated extracts fraction 4 F4 of fruit cover was more potent than other fractions whereas among solvent crude extracts; the ethanol extracts from fruit cover EFC displayed more potent activity than other parts against both bacteria. The experimental results obtained from this study suggest that S. macrophylla is promising natural antibacterial. Some bioactive groups were screened by TLC and the results obtained were positive and this may warrant further research to determine the bioactive compounds.
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Abstract
The study was carried out to screen antimicrobial activity for a new natural nontoxic and effective antibiotic from plant extract. In this study Swietenia macrophylla King was selected and antibacterial activity of extracts from different parts leaf fruit cover seed cover with various solvents or different fractions of the extracts was evaluated. The antibacterial activity of these extracts was assessed against two multiple-drug-resistance bacteria strains namely Escherichia coli and Staphylococcus aureus using well diffusion method. For the antibacterial bioassay four concentrations 10 50 100 and 150 2 g/mL-‚� of each extract solutions were prepared. The antibacterial activity among extracts was extremely broad against both test organisms. Minimum inhibition concentration was done via serial dilution method. The MIC values of the extracts ranged from 8.1 to 21.2 g/mL-‚�. Among fractionated extracts fraction 4 F4 of fruit cover was more potent than other fractions whereas among solvent crude extracts; the ethanol extracts from fruit cover EFC displayed more potent activity than other parts against both bacteria. The experimental results obtained from this study suggest that S. macrophylla is promising natural antibacterial. Some bioactive groups were screened by TLC and the results obtained were positive and this may warrant further research to determine the bioactive compounds.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. QK99 M3S471 2012 Call Number. |
| AGROVOC Term: | Swietenia |
| AGROVOC Term: | Swietenia macrophylla |
| AGROVOC Term: | Screening tests |
| AGROVOC Term: | Fractionation |
| AGROVOC Term: | Plant extracts |
| AGROVOC Term: | Antimicrobial properties |
| AGROVOC Term: | Escherichia coli |
| AGROVOC Term: | Staphylococcus aureus |
| AGROVOC Term: | Growth inhibition |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:16 |
| URI: | http://webagris.upm.edu.my/id/eprint/13708 |
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