Citation
Hani I. B., . and Mazura M. P., . and Rasadah M. A., . and Fadzureena J., . and Zainon A. S., . (2013) Inhibition of xanthine oxidase by some selected medicinal plants. [Proceedings Paper]
Abstract
Xanthine oxidase enzyme catalyses the oxidation of hypoxanthine to xanthine and then to uric acid which plays a crucial role in gout. A total of 47 selected medicinal plants species have been evaluated for the enzyme inhibitory activity. Among the86 methanolic extracts 9 having greater than 70 inhibition which were classified as high and 24 sample exhibited moderate activity ranging from 40-69 inhibition. The most active was the methanol extract from Piper maingayi stem with 96.82 1.71 inhibition. The activity which was then followed immediately by the Tetracera maingayi leaves with 93.63 4.47 and Ganoderma lucidum fruiting body with 82.34 7.45. The percentage inhibition of allopurinol which used as positive control was 92.80 0.21. The study demonstrated that the effects of these medicinal plants used for the gout treatment were based at least in part on the xanthine oxidase inhibitory activity.
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Abstract
Xanthine oxidase enzyme catalyses the oxidation of hypoxanthine to xanthine and then to uric acid which plays a crucial role in gout. A total of 47 selected medicinal plants species have been evaluated for the enzyme inhibitory activity. Among the86 methanolic extracts 9 having greater than 70 inhibition which were classified as high and 24 sample exhibited moderate activity ranging from 40-69 inhibition. The most active was the methanol extract from Piper maingayi stem with 96.82 1.71 inhibition. The activity which was then followed immediately by the Tetracera maingayi leaves with 93.63 4.47 and Ganoderma lucidum fruiting body with 82.34 7.45. The percentage inhibition of allopurinol which used as positive control was 92.80 0.21. The study demonstrated that the effects of these medicinal plants used for the gout treatment were based at least in part on the xanthine oxidase inhibitory activity.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. QK99 M3S471 2012 Call Number |
| AGROVOC Term: | Medicinal plants |
| AGROVOC Term: | Enzyme activity |
| AGROVOC Term: | Plant extracts |
| AGROVOC Term: | Xanthine oxidase |
| AGROVOC Term: | Inhibition |
| AGROVOC Term: | Piper |
| AGROVOC Term: | Ganoderma lucidum |
| AGROVOC Term: | Medicinal properties |
| AGROVOC Term: | Traditional medicines |
| AGROVOC Term: | Gout |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:16 |
| URI: | http://webagris.upm.edu.my/id/eprint/13710 |
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