Citation
Muhammad Syamil A., . and Muhammad Haffiz J., . and Getha K., . and Ilham A., . and Roshan Jahn M. S., . and Vanessa Y., . and Amyra M. S., . (2013) Evaluation on selected Malaysian plants and actinobacteria for their anti-leishmanial activity. [Proceedings Paper]
Abstract
The neglected diseases are taking its toll on millions of human life every year without fail. The currently available treatment is either insufficient or non-existent and pharmaceutical companies; biasness towards this third world malady is not helping to improve the situation. Leishmaniasis is a disease transmitted by sandfly bites and is found to affect around 350 million people in about 88 countries worldwide. Though Malaysia is not included in the list of an affected country we are blessed with an enormous diversity of bioresources. As part of our social responsibility and awareness programme FRIM collaborates with DNDi Drugs for Neglected Diseases Initiatives to screen our biodiversity for potential candidates to treat cutaneous leishmaniasis to help the most affected third world countries. A promastigote stage of Leishmania major and human monocytic cell line THP-1 were used in an in-vitro model to study the anti-leishmaniaI activity. In the course of our screening programme for anti-Ieishmanial activity from Malaysian forest plants and soil microbes two plant samples CfPR 21-199-Fl and CfPR 21-213-F1 and three isolates of soil actinobacteria CfPR 23-104-06 CfPR 23-113-02 and CfPR 23-113-06 have been identified to exhibit notable anti-Ieishmenial activity.
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Abstract
The neglected diseases are taking its toll on millions of human life every year without fail. The currently available treatment is either insufficient or non-existent and pharmaceutical companies; biasness towards this third world malady is not helping to improve the situation. Leishmaniasis is a disease transmitted by sandfly bites and is found to affect around 350 million people in about 88 countries worldwide. Though Malaysia is not included in the list of an affected country we are blessed with an enormous diversity of bioresources. As part of our social responsibility and awareness programme FRIM collaborates with DNDi Drugs for Neglected Diseases Initiatives to screen our biodiversity for potential candidates to treat cutaneous leishmaniasis to help the most affected third world countries. A promastigote stage of Leishmania major and human monocytic cell line THP-1 were used in an in-vitro model to study the anti-leishmaniaI activity. In the course of our screening programme for anti-Ieishmanial activity from Malaysian forest plants and soil microbes two plant samples CfPR 21-199-Fl and CfPR 21-213-F1 and three isolates of soil actinobacteria CfPR 23-104-06 CfPR 23-113-02 and CfPR 23-113-06 have been identified to exhibit notable anti-Ieishmenial activity.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. QK99 M3S471 2012 Call Number. |
| AGROVOC Term: | Leishmaniasis |
| AGROVOC Term: | Parasitic diseases |
| AGROVOC Term: | Leishmania |
| AGROVOC Term: | Disease treatment |
| AGROVOC Term: | Plants |
| AGROVOC Term: | Soil microorganisms |
| AGROVOC Term: | Bacteria |
| AGROVOC Term: | Antiprotozoal properties |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:16 |
| URI: | http://webagris.upm.edu.my/id/eprint/13713 |
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