Citation
Norazsida R., . and Pakeer O., . and Muhammad Taher B., . and EI-Hady Hassan M., . (2013) Phytochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis Lour spreng. [Proceedings Paper]
Abstract
Phytochemical analysis on the crude ethanolic extract of leaves of Malaysian Plectranthus amboinensis Lour. Spreng was carried out to delineate the presence of its chemical constituents like alkaloid flavonoid saponin triterpenoid and phenolic compounds. Acute oral toxicity at one dose level of 5000 mgjkg as per DECO Guideline for Testing of Chemicals 423 was conducted to evaluate the safety of this extract to be consumed by humans. Twenty mice were divided into one control group and one experimental group. The mice were observed for signs of toxicity mortality weight changes and gross pathological changes. Results from phytochemical analysis indicated that only flavanoid was present in the extract. The acute oral toxicity test revealed that no mortality or evidence of adverse effects was observed in the treated mice. Studies on histopathological examination of kidneys and liver showed normal architecture suggesting no morphological changes. Thus this ethanolic extract of leave P. amboinensis can be considered as safe as it neither cause lethality nor adverse changes in mice.
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Abstract
Phytochemical analysis on the crude ethanolic extract of leaves of Malaysian Plectranthus amboinensis Lour. Spreng was carried out to delineate the presence of its chemical constituents like alkaloid flavonoid saponin triterpenoid and phenolic compounds. Acute oral toxicity at one dose level of 5000 mgjkg as per DECO Guideline for Testing of Chemicals 423 was conducted to evaluate the safety of this extract to be consumed by humans. Twenty mice were divided into one control group and one experimental group. The mice were observed for signs of toxicity mortality weight changes and gross pathological changes. Results from phytochemical analysis indicated that only flavanoid was present in the extract. The acute oral toxicity test revealed that no mortality or evidence of adverse effects was observed in the treated mice. Studies on histopathological examination of kidneys and liver showed normal architecture suggesting no morphological changes. Thus this ethanolic extract of leave P. amboinensis can be considered as safe as it neither cause lethality nor adverse changes in mice.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. QK99 M3S471 2012 Call Number. |
| AGROVOC Term: | Plectranthus |
| AGROVOC Term: | Medicinal plants |
| AGROVOC Term: | Phytochemistry |
| AGROVOC Term: | Chemical analysis methods |
| AGROVOC Term: | Histopathology |
| AGROVOC Term: | Leaf extracts |
| AGROVOC Term: | Flavonoids |
| AGROVOC Term: | Acute toxicity |
| AGROVOC Term: | Toxicity |
| AGROVOC Term: | Mortality |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:16 |
| URI: | http://webagris.upm.edu.my/id/eprint/13727 |
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