Aphrodisiac potential and preclinical evaluation on the extract of mangrove plants in coastal area of Sabah

Syamimi Khalid, . and Ana Sharmila Shafie, . and Mohd Helme Mohd Helan, . and Thavamanithevi Subramaniam, . and Joseph Tangah, . and Lim Chuan Gee, . and Ahmad Hazri Ab. Rashid, . and Aidawati Mohd. Shabery, . and Nurul Husna Abdullah, . and Zuleen Delina Fasya Abd. Ghani, . and Puziah Hashim, . and John Sugau, . and Noor Rabihah Aid, . and Sarifah Rejab, . (2016) Aphrodisiac potential and preclinical evaluation on the extract of mangrove plants in coastal area of Sabah. [Proceedings Paper]

In this study M. muticus and R. mucronata were chosen for preliminary investigation on aphrodisiac potential using animal model. In materials and methods The 50 ethanol extract of powder leaf were subjected to chemical profiling phytochemical analysis testosterone screening and preclinical evaluation. Preclinical study to access the safety of plant extracts was performed. In vivo investigation of aphrodisiac potentials on the crude extracts was determined by assessing the libido and sexual potency enhancement. From the findings phytochemical screenings showed the presence of saponins and steroids compound believed to be responsible for aphrodisiac properties. NRU toxicity results were used to estimate the starting dose for acute oral study as well as in vivo efficacy. Under the conditions of this study the acute oral toxicity of extracts was classified as Category 5 according to the Globally Harmonised System for the classification of chemicals. The LD‚‚ is greater than 2000 mg/kg body weight. The in vivo study has shown that the extract studied significantly increased the serum testosterone level in sexually experienced rats. Sexual desire libido and motivation are improved as evidenced by the reduction in mount latency while sexual performance is enhanced by the reduction of intromission latency.

Full text available from: Official URL: http://www.forest.sabah.gov.my/docs/frc/Other.Conf...

Abstract

In this study M. muticus and R. mucronata were chosen for preliminary investigation on aphrodisiac potential using animal model. In materials and methods The 50 ethanol extract of powder leaf were subjected to chemical profiling phytochemical analysis testosterone screening and preclinical evaluation. Preclinical study to access the safety of plant extracts was performed. In vivo investigation of aphrodisiac potentials on the crude extracts was determined by assessing the libido and sexual potency enhancement. From the findings phytochemical screenings showed the presence of saponins and steroids compound believed to be responsible for aphrodisiac properties. NRU toxicity results were used to estimate the starting dose for acute oral study as well as in vivo efficacy. Under the conditions of this study the acute oral toxicity of extracts was classified as Category 5 according to the Globally Harmonised System for the classification of chemicals. The LD‚‚ is greater than 2000 mg/kg body weight. The in vivo study has shown that the extract studied significantly increased the serum testosterone level in sexually experienced rats. Sexual desire libido and motivation are improved as evidenced by the reduction in mount latency while sexual performance is enhanced by the reduction of intromission latency.

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Item Type:	Proceedings Paper
AGROVOC Term:	Mangroves
AGROVOC Term:	Coastal area
AGROVOC Term:	Phytochemistry
AGROVOC Term:	In vivo experimentation
AGROVOC Term:	Mallotus euphorbiaceae
AGROVOC Term:	Rhizophora
AGROVOC Term:	Plant extracts
AGROVOC Term:	Saponins
AGROVOC Term:	Steroids
AGROVOC Term:	Toxicity
Geographical Term:	MALAYSIA
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 05:16
URI:	http://webagris.upm.edu.my/id/eprint/13777

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