Citation
Mohamed Saifulaman, . and Mohamed Said, . and Rozita Rosli, . and Rohana Mat Nor, . and Mohd Ilham Adenan, . and Lai Leslie Charles, . and Nasir Umar-Tsafe, . and Laily Din, . and Zaidah Zainal Ariffin, . (2003) Preliminary studies on the genotoxic potential of some local plant extracts. [Proceedings Paper]
Abstract
A purified compound Andrographolide AG and two crude extracts Goniothalamus GMUS and Manjakani MJKN are plant samples previously reported to have medicinal properties such as in hepatomegaly abortifacient and postnatal astringent effects respectively. In addition they were all reported to have potential anti-cancer effects against cancer cell lines in vitro. The aim of this study was to assess the genotoxic potential of these extracts along with a positive control ethylmethane sulphonate EMS in the Chinese Hamster Ovary CHO cell line as recommended by the United Kingdom Environmental Mutagen Society UKEMS. Our findings which indicate genotoxicity represent a basis for assessing the safety of these extracts for human consumption.
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Abstract
A purified compound Andrographolide AG and two crude extracts Goniothalamus GMUS and Manjakani MJKN are plant samples previously reported to have medicinal properties such as in hepatomegaly abortifacient and postnatal astringent effects respectively. In addition they were all reported to have potential anti-cancer effects against cancer cell lines in vitro. The aim of this study was to assess the genotoxic potential of these extracts along with a positive control ethylmethane sulphonate EMS in the Chinese Hamster Ovary CHO cell line as recommended by the United Kingdom Environmental Mutagen Society UKEMS. Our findings which indicate genotoxicity represent a basis for assessing the safety of these extracts for human consumption.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| AGROVOC Term: | Plant extracts |
| AGROVOC Term: | Genotoxic substances |
| AGROVOC Term: | Medicinal properties |
| AGROVOC Term: | Annonaceae |
| AGROVOC Term: | Ethylmethanesulphonate |
| AGROVOC Term: | Genotoxicity |
| AGROVOC Term: | Cytotoxicity |
| AGROVOC Term: | Cancer disease |
| AGROVOC Term: | Disease treatment |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:16 |
| URI: | http://webagris.upm.edu.my/id/eprint/13819 |
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