Current issues on improving public and occupational safety in the use of pesticides

Maddy K.T., . (1990) Current issues on improving public and occupational safety in the use of pesticides. [Proceedings Paper]

Exposure of users of pesticides containing active ingredients which have the potential of causing adverse effects especially chronic effects has to be accurately measured in order to make meaningful risk assessment and risks mitigation determinations. Acceptable methology in usually available to measure inhalation exposure however most pesticide exposure to workers in through the skin. Analysis of residues on cloth pads that had been worn on various parts of the body may provide an overestimate exposure than is the case when such studies are done on humans or other primates. The most useful data results from development of metabolism data in humans or at least in a suitable test animal with appropriate pharmacokinetic data inculding excretory data and then biologically manitoring blood urine saliva or faeces of persons working with the chemical under normal conditions. Recent exposure measurements of mixer/loader/applicator and hand-harvest worker to various chemicals in California fields have included dislogeable foliage residues as well as residues on skin and in urine. The latter work sometimes substantially reduces earlier human exposure estimates. Such data are used to reach safety and regulatory decisions. The goal is to avoid an inaccurate estimate exposure that can result from some current methods of exposure assessment and which can lead to unnecessary restrictions or cancellations of registrations of the many pesticide active ingredients now being found to produce significant adverse effects in new animal tests

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Abstract

Exposure of users of pesticides containing active ingredients which have the potential of causing adverse effects especially chronic effects has to be accurately measured in order to make meaningful risk assessment and risks mitigation determinations. Acceptable methology in usually available to measure inhalation exposure however most pesticide exposure to workers in through the skin. Analysis of residues on cloth pads that had been worn on various parts of the body may provide an overestimate exposure than is the case when such studies are done on humans or other primates. The most useful data results from development of metabolism data in humans or at least in a suitable test animal with appropriate pharmacokinetic data inculding excretory data and then biologically manitoring blood urine saliva or faeces of persons working with the chemical under normal conditions. Recent exposure measurements of mixer/loader/applicator and hand-harvest worker to various chemicals in California fields have included dislogeable foliage residues as well as residues on skin and in urine. The latter work sometimes substantially reduces earlier human exposure estimates. Such data are used to reach safety and regulatory decisions. The goal is to avoid an inaccurate estimate exposure that can result from some current methods of exposure assessment and which can lead to unnecessary restrictions or cancellations of registrations of the many pesticide active ingredients now being found to produce significant adverse effects in new animal tests

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Item Type:	Proceedings Paper
Additional Information:	4 tables 11 ref.; Summary En
AGROVOC Term:	PLAGUICIDAS
AGROVOC Term:	DISPOSITIVOS DE SEGURIDAD
AGROVOC Term:	SEGURIDAD EN EL TRABAJO
AGROVOC Term:	CONTROL QUIMICO
Geographical Term:	MALAYSIA
Depositing User:	Ms. Norfaezah Khomsan
Last Modified:	24 Apr 2025 05:26
URI:	http://webagris.upm.edu.my/id/eprint/14909

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