Citation
A. Nor Jawahir, . and S. Ganabadi, . and A. K. Arifah, . and H. C. Chen, . (2009) Effect of orally administrated L-arginine on MIA-induced osteoarthritis in rats. [Proceedings Paper]
Abstract
Effects of oral administration L-arginine were evaluated on experimentally-induced OA.Rats were induced with OA by intra-articular injection of 3mg/joint monosodium iodoacetate in their right stifle joint day 0. After 17 days of inductions 1.25 g/kg of L-arginine were given orally to the first group 30 mg/kg of celecoxib for second group and normal saline for the control group. Upon euthanasia day 45 samples of joint were collected. The joints were observed grossly and processed for hematoxylin and eosin and safranin-O fast green staining. Changes on the cartilage surface of the induced joint and thickening of the joint capsule were more severe in group treated with normal saline. Histopathological changes such as disorganization of chondrocytes erosion and fibrillation of cartilage surface subchondral changes and osteophyte formation were more severe in control group compared to L-arginine treated group. This study suggests that oral administration of L-arginine has protective effects on cartilage and may be an alternative treatment for OA.
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Abstract
Effects of oral administration L-arginine were evaluated on experimentally-induced OA.Rats were induced with OA by intra-articular injection of 3mg/joint monosodium iodoacetate in their right stifle joint day 0. After 17 days of inductions 1.25 g/kg of L-arginine were given orally to the first group 30 mg/kg of celecoxib for second group and normal saline for the control group. Upon euthanasia day 45 samples of joint were collected. The joints were observed grossly and processed for hematoxylin and eosin and safranin-O fast green staining. Changes on the cartilage surface of the induced joint and thickening of the joint capsule were more severe in group treated with normal saline. Histopathological changes such as disorganization of chondrocytes erosion and fibrillation of cartilage surface subchondral changes and osteophyte formation were more severe in control group compared to L-arginine treated group. This study suggests that oral administration of L-arginine has protective effects on cartilage and may be an alternative treatment for OA.
Additional Metadata
Item Type: | Proceedings Paper |
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Additional Information: | 1 tables |
AGROVOC Term: | Arginine |
AGROVOC Term: | Osteoarthritis |
AGROVOC Term: | Rats |
AGROVOC Term: | Oral administration |
AGROVOC Term: | Cartilage |
Geographical Term: | MALAYSIA |
Depositing User: | Ms. Norfaezah Khomsan |
Last Modified: | 24 Apr 2025 05:27 |
URI: | http://webagris.upm.edu.my/id/eprint/15791 |
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