Citation
Boedi Setiawan, . and Hartanta Barus, . and Teresia Ayu Yulaimarini Banjarnahor, . (2009) Melatonin as an antioxidant in experimental diabetes mellitus type 1. [Proceedings Paper]
Abstract
The aim of this research was to study the effect of melatonin as antioxidant like in experimental diabetes mellitus type 1. Thirty rats were divided into five groups P0 P1 P2 P3 and P4. Group PO as a negative control of diabetes were injected with normal saline 0.5 cc and group P1 a positive control were injected with alloxan 150 mg/kg without melatonin. Group P2 P3 and P4 received melatonin at 5 mg/kg 10 mg/kg and 15 mg/ kg respectively for seven days then on the eighth day alloxan was given at 150 mg/kg to induce diabetes. Blood samples were collected four days after alloxan injection to measure the level of blood glucose and histopatological change of langerhans cells. The data was analyzed by using ANOVA and continued with Duncan's Multiple Range Test. The result of the experiment showed that melatonin P2 P3 and P4 did not cause hyperglycemia thus melatonin could decrease the damage to the Langerhans cells. It could be concluded that Melatonin can be used to prevent damage to pancreas from free radical in male wistar rat Rat novergicus.
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Abstract
The aim of this research was to study the effect of melatonin as antioxidant like in experimental diabetes mellitus type 1. Thirty rats were divided into five groups P0 P1 P2 P3 and P4. Group PO as a negative control of diabetes were injected with normal saline 0.5 cc and group P1 a positive control were injected with alloxan 150 mg/kg without melatonin. Group P2 P3 and P4 received melatonin at 5 mg/kg 10 mg/kg and 15 mg/ kg respectively for seven days then on the eighth day alloxan was given at 150 mg/kg to induce diabetes. Blood samples were collected four days after alloxan injection to measure the level of blood glucose and histopatological change of langerhans cells. The data was analyzed by using ANOVA and continued with Duncan's Multiple Range Test. The result of the experiment showed that melatonin P2 P3 and P4 did not cause hyperglycemia thus melatonin could decrease the damage to the Langerhans cells. It could be concluded that Melatonin can be used to prevent damage to pancreas from free radical in male wistar rat Rat novergicus.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | 3ill. 8 ref. |
| AGROVOC Term: | Melatonin |
| AGROVOC Term: | Antioxidants |
| AGROVOC Term: | Diabetes mellitus |
| AGROVOC Term: | Hyperglycemia |
| AGROVOC Term: | Alloxan |
| AGROVOC Term: | Langerhans cells |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Norfaezah Khomsan |
| Last Modified: | 24 Apr 2025 05:27 |
| URI: | http://webagris.upm.edu.my/id/eprint/15792 |
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