Role of leptin in preventing osteoporosis

N. Hidajati, . and A. Ma'ruf, . (2009) Role of leptin in preventing osteoporosis. [Proceedings Paper]

The objective of this study was to identify leptin's role in the prevention of osteoporosis in obesity. This study used post test only design involving 32 female Wistar strain rats of 4 month-old as samples. These experimental animals received the following treatments; 18 rats received standard amount of feedings for 2 months 2 8 rats received feedings 10 less than the standard amount for 2 months 3 8 rats received feedings 10 more than the standard amount for 2 months 4 8 rats received feeding ad libitum for 2 months. At day 60 1.5 cc of blood was taken intra cardially for leptin levels by ELISA followed with bone density examination in metaphysical part of femoral bone using Ultrasound DBM Sonic 1200.or 4 times. Results showed that rats receiving 10 less than standard feeding had significant difference p 0.05 of leptin concentration than those of other treatments. Leptin level of rats receiving 10 less than standard feeding was the lowest as compared to other treatments while the leptin levels of rats receiving standard feeding 10 more than standard and ad libitum were not significantly different p 0 05. The provision of standard feeding 10 more and ad libitum was found to have significant effect p 0.05 on bone density. Rats receiving 10 less than standard feeding had the lower bone density and the density increased consecutively in rats receiving standard 10 more and ad libitum feeding. This indicates that increased bone density corresponds with increasing leptin levels in rats. The higher the leptin level the more the increase in bone density.

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Abstract

The objective of this study was to identify leptin's role in the prevention of osteoporosis in obesity. This study used post test only design involving 32 female Wistar strain rats of 4 month-old as samples. These experimental animals received the following treatments; 18 rats received standard amount of feedings for 2 months 2 8 rats received feedings 10 less than the standard amount for 2 months 3 8 rats received feedings 10 more than the standard amount for 2 months 4 8 rats received feeding ad libitum for 2 months. At day 60 1.5 cc of blood was taken intra cardially for leptin levels by ELISA followed with bone density examination in metaphysical part of femoral bone using Ultrasound DBM Sonic 1200.or 4 times. Results showed that rats receiving 10 less than standard feeding had significant difference p 0.05 of leptin concentration than those of other treatments. Leptin level of rats receiving 10 less than standard feeding was the lowest as compared to other treatments while the leptin levels of rats receiving standard feeding 10 more than standard and ad libitum were not significantly different p 0 05. The provision of standard feeding 10 more and ad libitum was found to have significant effect p 0.05 on bone density. Rats receiving 10 less than standard feeding had the lower bone density and the density increased consecutively in rats receiving standard 10 more and ad libitum feeding. This indicates that increased bone density corresponds with increasing leptin levels in rats. The higher the leptin level the more the increase in bone density.

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Item Type:	Proceedings Paper
Additional Information:	2 tables
AGROVOC Term:	Leptin
AGROVOC Term:	Obesity
AGROVOC Term:	Bone diseases
AGROVOC Term:	Osteoporosis
Geographical Term:	MALAYSIA
Depositing User:	Ms. Norfaezah Khomsan
Last Modified:	24 Apr 2025 05:27
URI:	http://webagris.upm.edu.my/id/eprint/15810

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