Utilisation of local resources - a case for starch

Riyanto T.W., . and Hadida H., . and Mohd Ibrahim N., . (2000) Utilisation of local resources - a case for starch. [Proceedings Paper]

The utilisation of local resources as pharmaceutical raw materials has always been of great research and commercial interest. Malaysia is rich in natural resources that have potential value as pharmaceutical actives or excipients. Starch is a common pharmaceutical excipient particularly in tablet manufacture where it acts as a binder disintegrant or diluent. It also possesses absorbent and emollient properties. As such starch is also used in dermatological products as well as in the form of a mucilage as an antidote for iodine poisoning. The use of cassava Dioscorea Canna arrowroot and palm starch as excipients for direct compression tablets was studied. From each of these plant sources starch was extracted isolated pregelatinised and dried. The physiochemical characteristics of the dry pregelatinised starch with only 2 per cent moisture content were examined. Tests that were conducted included microscopic analysis loss on drying density flowability angle of repose dilution potential and compressibility index. The various starches were then formulated into direct compression tablets where in compressibility enhancers were used to improve formulations when required. Starch 1500 was used as the standard for comparison. The tablets were then evaluated using compendial tests for content uniformity of content dissolution disintegration and uniformity of weight as well as non-compendial tests for hardness and friability. Results revealed that the pregelatinised dioscorea starch with the addition of a compressibility enhancer appeared to be the best excipient in this study.

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Abstract

The utilisation of local resources as pharmaceutical raw materials has always been of great research and commercial interest. Malaysia is rich in natural resources that have potential value as pharmaceutical actives or excipients. Starch is a common pharmaceutical excipient particularly in tablet manufacture where it acts as a binder disintegrant or diluent. It also possesses absorbent and emollient properties. As such starch is also used in dermatological products as well as in the form of a mucilage as an antidote for iodine poisoning. The use of cassava Dioscorea Canna arrowroot and palm starch as excipients for direct compression tablets was studied. From each of these plant sources starch was extracted isolated pregelatinised and dried. The physiochemical characteristics of the dry pregelatinised starch with only 2 per cent moisture content were examined. Tests that were conducted included microscopic analysis loss on drying density flowability angle of repose dilution potential and compressibility index. The various starches were then formulated into direct compression tablets where in compressibility enhancers were used to improve formulations when required. Starch 1500 was used as the standard for comparison. The tablets were then evaluated using compendial tests for content uniformity of content dissolution disintegration and uniformity of weight as well as non-compendial tests for hardness and friability. Results revealed that the pregelatinised dioscorea starch with the addition of a compressibility enhancer appeared to be the best excipient in this study.

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Item Type:	Proceedings Paper
Additional Information:	Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. RS164 S471 1999 Call Number
AGROVOC Term:	DIOSCOREA
AGROVOC Term:	CASSAVA
AGROVOC Term:	STARCH
AGROVOC Term:	DRUG PLANTS
AGROVOC Term:	NATURAL RESOURCES
AGROVOC Term:	FOOD RESOURCES
AGROVOC Term:	CANNA
AGROVOC Term:	POWDERS
AGROVOC Term:	DRUGS
AGROVOC Term:	MOULDING
Geographical Term:	MALAYSIA
Depositing User:	Ms. Norfaezah Khomsan
Last Modified:	24 Apr 2025 05:27
URI:	http://webagris.upm.edu.my/id/eprint/15889

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