Phenolic content, antioxidant and hepatoprotective activities of Sabah Hoya coronaria Blume

Muhammad Dawood Shah, . and Senty Vun-Sang, . and Mohammad Iqbal, . (2023) Phenolic content, antioxidant and hepatoprotective activities of Sabah Hoya coronaria Blume. Journal of Tropical Biology and Conservation (Malaysia), 20. pp. 203-217. ISSN 2550-1909

A common challenge that regularly results from oxidative stress is hepatic damage. This condition is characterised by a gradual progression from steatosis to chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. The study proposed to assess the antioxidant activity and efficacy of Hoya coronaria aqueous extract in preventing CCI₄-induced hepatic damage in rats. The DPPH technique was used in the study to assess the extract's antioxidant properties. The rats received dosages of 125 and 250 mg/kg body weight of H. coronaria extract for 14 days, followed by CCI₄ exposure. After two weeks, the rats were euthanised for analysis. The results indicated that the extract showed significant antioxidant potential and decreased the impact of CCI₄ on hepatic damage markers such as serum aspartate transaminase and alanine transaminase. Moreover, it increased hepatic reduced glutathione and various antioxidant enzymes while reducing malondialdehyde formation induced by CCI₄. Additionally, the histopathological analysis demonstrated that H. coronaria extract protected the liver against fatty degeneration and necrosis induced by CCI₄ toxicity. These outcomes suggest that H. coronaria extract could be used to prevent ROS-related hepatic damage.

Full text available from: Official URL: https://jurcon.ums.edu.my/ojums/index.php/jtbc/art...

Abstract

A common challenge that regularly results from oxidative stress is hepatic damage. This condition is characterised by a gradual progression from steatosis to chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. The study proposed to assess the antioxidant activity and efficacy of Hoya coronaria aqueous extract in preventing CCI₄-induced hepatic damage in rats. The DPPH technique was used in the study to assess the extract's antioxidant properties. The rats received dosages of 125 and 250 mg/kg body weight of H. coronaria extract for 14 days, followed by CCI₄ exposure. After two weeks, the rats were euthanised for analysis. The results indicated that the extract showed significant antioxidant potential and decreased the impact of CCI₄ on hepatic damage markers such as serum aspartate transaminase and alanine transaminase. Moreover, it increased hepatic reduced glutathione and various antioxidant enzymes while reducing malondialdehyde formation induced by CCI₄. Additionally, the histopathological analysis demonstrated that H. coronaria extract protected the liver against fatty degeneration and necrosis induced by CCI₄ toxicity. These outcomes suggest that H. coronaria extract could be used to prevent ROS-related hepatic damage.

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Item Type:	Article
AGROVOC Term:	medicinal plants
AGROVOC Term:	phenolic compounds
AGROVOC Term:	antioxidants
AGROVOC Term:	phytochemistry
AGROVOC Term:	oxidative stress
AGROVOC Term:	experimental design
AGROVOC Term:	statistical methods
AGROVOC Term:	plant extracts
AGROVOC Term:	human health
AGROVOC Term:	bioactive compounds
Geographical Term:	Malaysia
Uncontrolled Keywords:	Hoya coronaria
Depositing User:	Ms. Azariah Hashim
Date Deposited:	17 Nov 2025 08:13
Last Modified:	17 Nov 2025 08:13
URI:	http://webagris.upm.edu.my/id/eprint/1649

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