A systematic review of antimicrobial peptides from fish with anticancer properties

Najm, Ahmed Abdulkareem and Ahmad Azfaralarriff and Dyari, Herryawan Ryadi Eziwar and Sharifah Sakinah Syed Alwi and Khalili, Nahid and Babul Airianah Othman and Law, Douglas and Muhammad Shahid and Shazrul Fazry. (2022) A systematic review of antimicrobial peptides from fish with anticancer properties. Pertanika Journal of Science & Technology (Malaysia), 30 (2). 1171 -1196. ISSN 2231-8526

Fish is a potential source of various forms of bioactive compounds. It can be used as a source of specific proteins, especially in medicine. Recently, studies related to the use of antimicrobial peptides (AMPs) from fish are being carried out to find an alternative cure for cancer. To achieve this objective, the AMP used must meet a condition where it possesses the ability to target tumor cells without affecting the normal cell. Therefore, this study aims to systematically review and classify the recent AMPs isolated from fish and their therapeutic activities, focusing on their anticancer and antimicrobial activities. A systematic review of studies published in English between 2017 and 2020 was conducted in PubMed NCBI, Biomed Central, Science Direct, and Google Scholar databases using keywords and inclusion and exclusion criteria. A systematic review conducted has identified 38 potential AMPs isolated from fish that have been reported to have antimicrobials activity. Of all of these, 21 AMPs also have anticancer properties. Therefore, it is important to continue to explore and study natural ingredients in developing new approaches in medicine. This research is essential to enable the potential of AMPs to be identified and applied.

Full text available from: Official URL: http://www.pertanika.upm.edu.my/resources/files/Pe...

Abstract

Fish is a potential source of various forms of bioactive compounds. It can be used as a source of specific proteins, especially in medicine. Recently, studies related to the use of antimicrobial peptides (AMPs) from fish are being carried out to find an alternative cure for cancer. To achieve this objective, the AMP used must meet a condition where it possesses the ability to target tumor cells without affecting the normal cell. Therefore, this study aims to systematically review and classify the recent AMPs isolated from fish and their therapeutic activities, focusing on their anticancer and antimicrobial activities. A systematic review of studies published in English between 2017 and 2020 was conducted in PubMed NCBI, Biomed Central, Science Direct, and Google Scholar databases using keywords and inclusion and exclusion criteria. A systematic review conducted has identified 38 potential AMPs isolated from fish that have been reported to have antimicrobials activity. Of all of these, 21 AMPs also have anticancer properties. Therefore, it is important to continue to explore and study natural ingredients in developing new approaches in medicine. This research is essential to enable the potential of AMPs to be identified and applied.

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Item Type:	Article
AGROVOC Term:	fish
AGROVOC Term:	peptides
AGROVOC Term:	antimicrobials
AGROVOC Term:	systematic reviews
AGROVOC Term:	bioactive compounds
AGROVOC Term:	neoplasms
AGROVOC Term:	medicinal properties
Geographical Term:	Malaysia
Uncontrolled Keywords:	Antimicrobial peptides, antitumor activity, fish, medicinal agents
Depositing User:	Ms. Azariah Hashim
Date Deposited:	12 Nov 2024 02:20
Last Modified:	12 Nov 2024 02:20
URI:	http://webagris.upm.edu.my/id/eprint/1742

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