Citation
Madihah Md Salleh, . and Arbakariya Ariff, . and Mohd Ali Hassan, . and Gulam Rusul, . and Mohamed Ismail Abdul Karim, . Enhanced kojic acid production by Aspergillus flavus Link in growth medium containing methanol. pp. 158-162. ISSN 1505-5337
Abstract
The effect of different methanol concentrations (1-6 percent v/v) in growth medium on kojic acid production by Aspergillus flavus Link was studied using shake flask experiments. A slight growth inhibition of A. flavus in medium containing methanol at concentrations of up to 4 percent (v/v) was observed; however kojic acid production was greatly enhanced. Both growth and kojic acid production were greaty inhibited when methanol concentration of above 5 percent (v/v) was used. The highest kojic acid production (40.7-41.7 g/L) was obtained in medium with 3-4 percent (v/v) methanol which gave the yield based on glucose consumed and overall productivity of about 0.47 g/g and 0.072 g/L.h respectively. In comparison to fermentation with no methanol the improvement of kojic acid production in terms of maximum concentration yield based on glucose consumed and overall productivity was 2 4.6 and 1.7 times higher respectively. The average size of the pellets depended on the concentration of methanol added to the medium. A linear inverse relationship between kojic acid production and pellet size was observed suggesting that kojic acid production depends on the oxygen transfer rate.
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Abstract
The effect of different methanol concentrations (1-6 percent v/v) in growth medium on kojic acid production by Aspergillus flavus Link was studied using shake flask experiments. A slight growth inhibition of A. flavus in medium containing methanol at concentrations of up to 4 percent (v/v) was observed; however kojic acid production was greatly enhanced. Both growth and kojic acid production were greaty inhibited when methanol concentration of above 5 percent (v/v) was used. The highest kojic acid production (40.7-41.7 g/L) was obtained in medium with 3-4 percent (v/v) methanol which gave the yield based on glucose consumed and overall productivity of about 0.47 g/g and 0.072 g/L.h respectively. In comparison to fermentation with no methanol the improvement of kojic acid production in terms of maximum concentration yield based on glucose consumed and overall productivity was 2 4.6 and 1.7 times higher respectively. The average size of the pellets depended on the concentration of methanol added to the medium. A linear inverse relationship between kojic acid production and pellet size was observed suggesting that kojic acid production depends on the oxygen transfer rate.
Additional Metadata
| Item Type: | Article |
|---|---|
| Additional Information: | Summary (En) |
| AGROVOC Term: | KOJIC ACID |
| AGROVOC Term: | ASPERGILLUS FLAVUS |
| AGROVOC Term: | GROWING MEDIA |
| AGROVOC Term: | METHANOL |
| AGROVOC Term: | MICROORGANISMS |
| AGROVOC Term: | FERMENTATION |
| AGROVOC Term: | ANALYTICAL METHODS |
| AGROVOC Term: | GLUCOSE |
| AGROVOC Term: | MALAYSIA ACIDO COJICO |
| AGROVOC Term: | ASPERGILLUS FLAVUS |
| Depositing User: | Ms. Norfaezah Khomsan |
| Last Modified: | 24 Apr 2025 05:52 |
| URI: | http://webagris.upm.edu.my/id/eprint/17437 |
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