In vitro inhibition of acetylcholinesterase by acephate and methamidophos

Rosli bin Mohamad, . In vitro inhibition of acetylcholinesterase by acephate and methamidophos. pp. 55-61. ISSN 0127-6883

Inhibition of the acetylcholinesterase (AChE) of two insects laboratory rat and human by acephate and methamidophos insecticides was evaluated in vitro. Acephate in itself is capable of inhibiting AChE to some extent immediately as well as for a prolonged period. The inhibition by methamidophos progressed faster during the first 20 to 30 min of exposure but not immediately. The pattern of inhibition of the AChE by both insecticides followed that of paraoxon and are non-reversible. Incubation of AChE with acephate and methamidophos together did not produce inhibition of synergistic effect but could only be considered as additive.

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Abstract

Inhibition of the acetylcholinesterase (AChE) of two insects laboratory rat and human by acephate and methamidophos insecticides was evaluated in vitro. Acephate in itself is capable of inhibiting AChE to some extent immediately as well as for a prolonged period. The inhibition by methamidophos progressed faster during the first 20 to 30 min of exposure but not immediately. The pattern of inhibition of the AChE by both insecticides followed that of paraoxon and are non-reversible. Incubation of AChE with acephate and methamidophos together did not produce inhibition of synergistic effect but could only be considered as additive.

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Item Type:	Article
Additional Information:	4 graphs; 2 tables; 14 ref. Summary (En Malay)
AGROVOC Term:	INSECTICIDAS
AGROVOC Term:	ACETILCOLINESTERASA/ INHIBIDORES DE ENZIMAS
AGROVOC Term:	EXPERIMENTACION IN VITRO
Depositing User:	Ms. Norfaezah Khomsan
Last Modified:	24 Apr 2025 05:56
URI:	http://webagris.upm.edu.my/id/eprint/20323

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