Citation
Norhayati I., . and Getha K., . and Muhd Haffiz J., . and Mohd Ilham A., . and Lili Sahira H., . and Siti Syarifah M. M., . and Muhd Syamil A., . In vitro antitrypanosomal activity of Malaysian plants. pp. 52-59. ISSN 0128-1283
Abstract
A total of 119 plant species collected from different localities in Malaysia were screened for in vitro antitrypanosomal activity. A hundred and forty methanol extracts prepared from different plant parts were tested on Trypanosoma brucei brucei strain BS221. Extracts were also tested for their cytotoxic activities on a mamalian cell line (Vero) to determine their selectivity towards the parasite. For the first time antitrypanosomal activity was identified in the leaves of Dyera costulata and the whole plant of Cymbopogon nardus with IC50 values of 0.58 0.01 g mL-1 (selectivity index SI 169) and 0.31 0.03 g mL-1 (SI 323) respectively. These plants could be attractive candidates for treatment of sleeping sickness.
Download File
Full text available from:
Official URL: http://www.frim.gov.my/v1/JTFSOnline/jtfs/v25n1/52...
|
Abstract
A total of 119 plant species collected from different localities in Malaysia were screened for in vitro antitrypanosomal activity. A hundred and forty methanol extracts prepared from different plant parts were tested on Trypanosoma brucei brucei strain BS221. Extracts were also tested for their cytotoxic activities on a mamalian cell line (Vero) to determine their selectivity towards the parasite. For the first time antitrypanosomal activity was identified in the leaves of Dyera costulata and the whole plant of Cymbopogon nardus with IC50 values of 0.58 0.01 g mL-1 (selectivity index SI 169) and 0.31 0.03 g mL-1 (SI 323) respectively. These plants could be attractive candidates for treatment of sleeping sickness.
Additional Metadata
| Item Type: | Article |
|---|---|
| AGROVOC Term: | In vitro |
| AGROVOC Term: | Methanol |
| AGROVOC Term: | Extracts |
| AGROVOC Term: | Trypanosoma brucei |
| AGROVOC Term: | Cytotoxicity |
| AGROVOC Term: | Dyera costulata |
| AGROVOC Term: | Cymbopogon |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 06:26 |
| URI: | http://webagris.upm.edu.my/id/eprint/21224 |
Actions (login required)
 |
View Item |
