Triterpenoid-rich fraction of Centella asiatica leaves and in vivo antihypertensive activity


Citation

Harwoko, . and Pramono S., . and Nugroho A. E., . Triterpenoid-rich fraction of Centella asiatica leaves and in vivo antihypertensive activity. pp. 149-154.

Abstract

Antihypertensive herbs in scientification of jamu� program in Indonesia contained Centella asiatica (L.) Urban. The leaf contains several compounds such as triterpenoids flavonoids phenolics tannins and resins. The total triterpenic fraction of C. asiatica could treat venous hypertensive microangiopathy while ethyl acetate fraction of C. asiatica leaf has hypotensive effect in cats. This study aimed to provide triterpenoid-rich fraction of C. asiatica leaf to analyze asiaticoside contents and to examine the in vivo antihypertensive effect on phenylephrine-induced hypertensive rats by non-invasive tail-cuff method. The results showed that triterpenoid contents in chloroform fraction of C. asiatica (CFCA) were more dominant than the flavonoid/phenolic contents. TLC-densitometric data showed that asiaticoside contents of CFCA were 0.402 0.02. The CFCA showed antihypertensive effect on phenylephrine-induced hypertensive rats. The ED50 values a parameter of drug potency of these effects on systolic blood pressure diastolic blood pressure and mean arterial pressure were 10.40 0.98 9.05 1.95 and 9.37 1.69 mg/kg respectively.


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Abstract

Antihypertensive herbs in scientification of jamu� program in Indonesia contained Centella asiatica (L.) Urban. The leaf contains several compounds such as triterpenoids flavonoids phenolics tannins and resins. The total triterpenic fraction of C. asiatica could treat venous hypertensive microangiopathy while ethyl acetate fraction of C. asiatica leaf has hypotensive effect in cats. This study aimed to provide triterpenoid-rich fraction of C. asiatica leaf to analyze asiaticoside contents and to examine the in vivo antihypertensive effect on phenylephrine-induced hypertensive rats by non-invasive tail-cuff method. The results showed that triterpenoid contents in chloroform fraction of C. asiatica (CFCA) were more dominant than the flavonoid/phenolic contents. TLC-densitometric data showed that asiaticoside contents of CFCA were 0.402 0.02. The CFCA showed antihypertensive effect on phenylephrine-induced hypertensive rats. The ED50 values a parameter of drug potency of these effects on systolic blood pressure diastolic blood pressure and mean arterial pressure were 10.40 0.98 9.05 1.95 and 9.37 1.69 mg/kg respectively.

Additional Metadata

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Item Type: Article
AGROVOC Term: Triterpenoids
AGROVOC Term: Leaves
AGROVOC Term: Apiaceae
AGROVOC Term: In vivo experimentation
AGROVOC Term: Antihypertensive agents
AGROVOC Term: Herbs (herbaceous plants)
AGROVOC Term: Resins
AGROVOC Term: Triterpenoids
AGROVOC Term: Flavonoids
AGROVOC Term: Phenolic compounds
Depositing User: Ms. Suzila Mohamad Kasim
Last Modified: 24 Apr 2025 06:26
URI: http://webagris.upm.edu.my/id/eprint/21263

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