Evaluation of mixture effects in binary solutions of ascorbic acid with grape (Vitis vinifera) seed extracts using Response Surface Methodology

Karvela E., . and Makris D. P., . and Karathanos V. T., . Evaluation of mixture effects in binary solutions of ascorbic acid with grape (Vitis vinifera) seed extracts using Response Surface Methodology. pp. 2193-2198. ISSN 22317546

acid (AA) to evaluate the effects on the antiradical behaviour using the DPPH assay. The investigations aimed at illustrating possible mixture effects manifested either as synergism or as antagonism. By employing a simple linear regression approach combinations of all extracts exhibited antagonism when combined with AA at concentration ratio of 1:1. Furthermore to thoroughly investigate the role of the relative concentrations of the antioxidants a 33 factorial design was implemented. This approach enabled the recording of the responses upon simultaneous variation of both the polyphenol concentration of the extracts and AA in the mixtures. In this case too it was demonstrated that combinations of grape seed extracts with AA resulted in antagonism. This effect was discussed on the basis of grape seed composition and plausible antioxidant interactions.

Full text available from: Official URL: http://ifrj.upm.edu.my/20%20(05)%202013/20%20IFRJ%...

Abstract

acid (AA) to evaluate the effects on the antiradical behaviour using the DPPH assay. The investigations aimed at illustrating possible mixture effects manifested either as synergism or as antagonism. By employing a simple linear regression approach combinations of all extracts exhibited antagonism when combined with AA at concentration ratio of 1:1. Furthermore to thoroughly investigate the role of the relative concentrations of the antioxidants a 33 factorial design was implemented. This approach enabled the recording of the responses upon simultaneous variation of both the polyphenol concentration of the extracts and AA in the mixtures. In this case too it was demonstrated that combinations of grape seed extracts with AA resulted in antagonism. This effect was discussed on the basis of grape seed composition and plausible antioxidant interactions.

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Item Type:	Article
AGROVOC Term:	Ascorbic acid
AGROVOC Term:	Vitis vinifera
AGROVOC Term:	Grapes
AGROVOC Term:	Seed extracts
AGROVOC Term:	Surface measure
AGROVOC Term:	Synergism
AGROVOC Term:	Antagonism
AGROVOC Term:	Antioxidants
AGROVOC Term:	Polyphenols
AGROVOC Term:	Oxidation
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:26
URI:	http://webagris.upm.edu.my/id/eprint/21324

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