Garlic: an effective functional food to combat the growing antimicrobial resistance

Gupta Shivani, . and Kapur Suman, . and Padmavathi D. V., . and Verma Apoorva., . Garlic: an effective functional food to combat the growing antimicrobial resistance. pp. 271-278. ISSN PertanikaJ.Trop.Agric.Sci.38(2):271-278(2015)ISSN:1511-3701

Emerging multidrug resistant bacterial infections are burning public health concerns worldwide. There is an urgent need to explore alternative antimicrobial agents for effective management of bacterial infections. Garlic (Allium sativum) has been traditionally used for the treatment of different diseases since ancient times. The present study aims to evaluate the antimicrobial activity of aqueous extract of Allium sativum against multidrug resistant clinical isolates of pathogenic bacteria found in human urine in cases of urinary tract infection (UTI). A total of 166 uropathogens were evaluated for antibiotic susceptibility 56 clinical isolates were found to have high degree of resistance with multiple antibiotic resistance (MAR) index 0.5. About 82 bacterial isolates with MAR index 0.5 were found to be susceptible to crude aqueous garlic extract. Thus aqueous garlic extract (AGE) was found to possess effective anti-bacterial activity against multidrug resistant clinical pathogens and may be tested further as a natural dietary component to manage drug resistance bacteraemia. Therefore alternate medicine practices with natural plant extract including garlic may be of great importance in combating public health challenges like UTI.

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Abstract

Emerging multidrug resistant bacterial infections are burning public health concerns worldwide. There is an urgent need to explore alternative antimicrobial agents for effective management of bacterial infections. Garlic (Allium sativum) has been traditionally used for the treatment of different diseases since ancient times. The present study aims to evaluate the antimicrobial activity of aqueous extract of Allium sativum against multidrug resistant clinical isolates of pathogenic bacteria found in human urine in cases of urinary tract infection (UTI). A total of 166 uropathogens were evaluated for antibiotic susceptibility 56 clinical isolates were found to have high degree of resistance with multiple antibiotic resistance (MAR) index 0.5. About 82 bacterial isolates with MAR index 0.5 were found to be susceptible to crude aqueous garlic extract. Thus aqueous garlic extract (AGE) was found to possess effective anti-bacterial activity against multidrug resistant clinical pathogens and may be tested further as a natural dietary component to manage drug resistance bacteraemia. Therefore alternate medicine practices with natural plant extract including garlic may be of great importance in combating public health challenges like UTI.

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Item Type:	Article
AGROVOC Term:	Garlic
AGROVOC Term:	Antimicrobial resistance
AGROVOC Term:	Functional foods
AGROVOC Term:	Public health
AGROVOC Term:	Allium sativum
AGROVOC Term:	Pathogenic bacteria
AGROVOC Term:	Urinary tract diseases
AGROVOC Term:	Antibiotic resistance
AGROVOC Term:	Enterobacter
AGROVOC Term:	Klebsiella
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:27
URI:	http://webagris.upm.edu.my/id/eprint/21646

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