Anticancer effect of underutilized fruits

Lam K. L, . and Chan S, . and Ong M. T, . and Rabeta M. S, . and Neda G. D, . Anticancer effect of underutilized fruits. pp. 551-556. ISSN 22317546

Plants particularly fruits and vegetables have many phytochemicals that possess various bioactivities including antioxidant and anticancer properties. In this study the aim was to investigate the antiproliferative properties of Syzygium fruits namely water apple (Syzygium aqueum) milk apple (Syzygium malaccense) and malay apple (Syzygium malaccense L.) against two types of cancer-origin cells namely MCF-7 (hormone dependent breast cancer cell line) and MDA-MB-231 (nonhormone-dependent breast cancer cell line). Two solvent methods were prepared using aqueous and methanol extraction. Antiproliferation activities of these extracts were evaluated by employing colorimetric MTT (3-(4 5-dimethylthiazol-2-yl)2 5 diphenyltetrazolium bromide) assay through time periods of 24 48 and 72 hours. The result showed that extracts from the three fruits had no significant effects for 24 and 48 hours time periods (p 0.05) but extracts of Water apple and Malay apple displayed antiproliferation effects on MCF-7 cell lines (p 0.05) in 72 hours also there were no effects on the non-cancer origin cell line. The methanolic extracts of the malay apple was more significant with 79 cell viability in the case of MCF7 (IC50 632.3 g/ml). However extracts of the milk apple did show antiproliferation effects on both cancer origin and non cancer-origin cell lines (p 0.05) in 72 hours. This finding revealed that fruits extract exhibit antiproliferative activity against MCF-7 which is strongly estrogen-dependant probably due to extract compound responsible for its anticancer properties. Many studies had shown that plant polyphenols may prevent the metastasis of breast cancer cells through common pathway.

Full text available from: Official URL: http://ifrj.upm.edu.my/20%20(02)%202013/6%20IFRJ%2...

Abstract

Plants particularly fruits and vegetables have many phytochemicals that possess various bioactivities including antioxidant and anticancer properties. In this study the aim was to investigate the antiproliferative properties of Syzygium fruits namely water apple (Syzygium aqueum) milk apple (Syzygium malaccense) and malay apple (Syzygium malaccense L.) against two types of cancer-origin cells namely MCF-7 (hormone dependent breast cancer cell line) and MDA-MB-231 (nonhormone-dependent breast cancer cell line). Two solvent methods were prepared using aqueous and methanol extraction. Antiproliferation activities of these extracts were evaluated by employing colorimetric MTT (3-(4 5-dimethylthiazol-2-yl)2 5 diphenyltetrazolium bromide) assay through time periods of 24 48 and 72 hours. The result showed that extracts from the three fruits had no significant effects for 24 and 48 hours time periods (p 0.05) but extracts of Water apple and Malay apple displayed antiproliferation effects on MCF-7 cell lines (p 0.05) in 72 hours also there were no effects on the non-cancer origin cell line. The methanolic extracts of the malay apple was more significant with 79 cell viability in the case of MCF7 (IC50 632.3 g/ml). However extracts of the milk apple did show antiproliferation effects on both cancer origin and non cancer-origin cell lines (p 0.05) in 72 hours. This finding revealed that fruits extract exhibit antiproliferative activity against MCF-7 which is strongly estrogen-dependant probably due to extract compound responsible for its anticancer properties. Many studies had shown that plant polyphenols may prevent the metastasis of breast cancer cells through common pathway.

[error in script]

Item Type:	Article
AGROVOC Term:	Apples
AGROVOC Term:	Malay apple
AGROVOC Term:	Cancer (disease)
AGROVOC Term:	Syzygium malaccensis
AGROVOC Term:	Syzygium aqueum
AGROVOC Term:	Lymphocyte proliferation
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:27
URI:	http://webagris.upm.edu.my/id/eprint/21764

Actions (login required)

View Item