In vivo antidiabetic and acute toxicity of spray-dried Vernonia amygdalina water extract

Beh Boon Kee, . and Liang W.S, . and Ho Wan Yong, . and Yousr A.N, . and Yeap Swee Keong, . and Alitheen Norjahan Banu, . In vivo antidiabetic and acute toxicity of spray-dried Vernonia amygdalina water extract. pp. 613-616. ISSN 22317546

The spray-dried Vernonia amygdalina water extract was evaluated for antidiabetic effect using normoglycaemic glucose induced hyperglycaemic and streptozotocin induced diabetic mice. This effect was compared with an oral dose of Momordica charantia. Besides acute toxicity of the extract was also evaluated at concentration 2000 and 5000 mg/kg body weight. The extract was able to reduce blood glucose level in glucose and streptozotocin induced hyperglycaemic mice without causing hypoglycemic effect on fasting normoglycaemic mice. Moreover mice appeared to be normal and no mortality was observed in the acute toxicity study after treated with up to 5000mg/kg of extract. These results indicated that the spray-dried Vernonia amygdalina water extract was a potential antidiabetic agent which does not induce hypoglycemic and acute toxicity on normal subject.

Full text available from: Official URL: http://ifrj.upm.edu.my/20%20(02)%202013/15%20IFRJ%...

Abstract

The spray-dried Vernonia amygdalina water extract was evaluated for antidiabetic effect using normoglycaemic glucose induced hyperglycaemic and streptozotocin induced diabetic mice. This effect was compared with an oral dose of Momordica charantia. Besides acute toxicity of the extract was also evaluated at concentration 2000 and 5000 mg/kg body weight. The extract was able to reduce blood glucose level in glucose and streptozotocin induced hyperglycaemic mice without causing hypoglycemic effect on fasting normoglycaemic mice. Moreover mice appeared to be normal and no mortality was observed in the acute toxicity study after treated with up to 5000mg/kg of extract. These results indicated that the spray-dried Vernonia amygdalina water extract was a potential antidiabetic agent which does not induce hypoglycemic and acute toxicity on normal subject.

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Item Type:	Article
AGROVOC Term:	Acute toxicity
AGROVOC Term:	In vivo experimentation
AGROVOC Term:	Vernonia
AGROVOC Term:	Blood glucose
AGROVOC Term:	Glucose
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:27
URI:	http://webagris.upm.edu.my/id/eprint/21773

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